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Luminal DMSO : Effects on Detrusor and UrothelialLamina Propria Function
Joint Authors
Smith, Katrina J.
McDermott, Catherine
Chess-Williams, Russ
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
DMSO is used as a treatment for interstitial cystitis and this study examined the effects of luminal DMSO treatment on bladder function and histology.
Porcine bladder was incubated without (controls) or with DMSO (50%) applied to the luminal surface and the release of ATP, acetylcholine, and LDH assessed during incubation and in tissues strips after DMSO incubation.
Luminally applied DMSO caused ATP, Ach, and LDH release from the urothelial surface during treatment, with loss of urothelial layers also evident histologically.
In strips of urothelium/lamina propria from DMSO pretreated bladders the release of both ATP and Ach was depressed, while contractile responses to carbachol were enhanced.
Detrusor muscle contractile responses to carbachol were not affected by DMSO pretreatment, but neurogenic responses to electrical field stimulation were enhanced.
The presence of an intact urothelium/lamina propria inhibited detrusor contraction to carbachol by 53% and this inhibition was significantly reduced in DMSO pretreated tissues.
Detection of LDH in the treatment medium suggests that DMSO permeabilised urothelial membranes causing leakage of cytosolic contents including ATP and Ach rather than enhancing release of these mediators.
The increase in contractile response and high levels of ATP are consistent with initial flare up in IC/PBS symptoms after DMSO treatment.
American Psychological Association (APA)
Smith, Katrina J.& Chess-Williams, Russ& McDermott, Catherine. 2014. Luminal DMSO : Effects on Detrusor and UrothelialLamina Propria Function. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-464664
Modern Language Association (MLA)
Smith, Katrina J.…[et al.]. Luminal DMSO : Effects on Detrusor and UrothelialLamina Propria Function. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-464664
American Medical Association (AMA)
Smith, Katrina J.& Chess-Williams, Russ& McDermott, Catherine. Luminal DMSO : Effects on Detrusor and UrothelialLamina Propria Function. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-464664
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464664