Synthesis, Cytotoxic Activity, and DNA Binding Properties of Copper (II) Complexes with Hesperetin, Naringenin, and Apigenin
Joint Authors
Tan, Mingxiong
Pan, Yingming
Wang, Hengshan
Liang, Hong
Liu, Huagang
Zhu, Jinchan
Chen, Zhen-Feng
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-10-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Complexes of copper (II) with hesperetin, naringenin, and apigenin of general composition [CuL2(H2O)2]⋅nH2O (1–3) have been synthesized and characterized by elemental analysis, UV-Vis, FT-IR, ESI-MS, and TG-DTG thermal analysis.
The free ligands and the metal complexes have been tested in vitro against human cancer cell lines hepatocellular carcinoma (HepG-2), gastric carcinomas (SGC-7901), and cervical carcinoma (HeLa).
Complexes 1 and 3 were found to exhibit growth inhibition of SGC-7901 and HepG2 cell lines with respect to the free ligands; the inhibitory rate of complex 1 is 43.2% and 43.8%, while complex 3 is 46% and 36%, respectively.
The interactions of complex 1 and its ligand Hsp with calf thymus DNA were investigated by UV-Vis, fluorescence, and CD spectra.
Both complex 1 and Hsp were found to bind DNA in intercalation modes, and the binding affinity of complex 1 was stronger than that of free ligand.
American Psychological Association (APA)
Tan, Mingxiong& Zhu, Jinchan& Pan, Yingming& Chen, Zhen-Feng& Liang, Hong& Liu, Huagang…[et al.]. 2009. Synthesis, Cytotoxic Activity, and DNA Binding Properties of Copper (II) Complexes with Hesperetin, Naringenin, and Apigenin. Bioinorganic Chemistry and Applications،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-464679
Modern Language Association (MLA)
Tan, Mingxiong…[et al.]. Synthesis, Cytotoxic Activity, and DNA Binding Properties of Copper (II) Complexes with Hesperetin, Naringenin, and Apigenin. Bioinorganic Chemistry and Applications No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-464679
American Medical Association (AMA)
Tan, Mingxiong& Zhu, Jinchan& Pan, Yingming& Chen, Zhen-Feng& Liang, Hong& Liu, Huagang…[et al.]. Synthesis, Cytotoxic Activity, and DNA Binding Properties of Copper (II) Complexes with Hesperetin, Naringenin, and Apigenin. Bioinorganic Chemistry and Applications. 2009. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-464679
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464679
