The Role of the Immune Response in Age-Related Macular Degeneration
Joint Authors
Holers, V. Michael
Whitcup, Scott M.
Atkinson, John P.
Sinha, Debasish
Sodhi, Akrit
Rohrer, Bärbel
Dick, Andrew D.
Source
International Journal of Inflammation
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries; with the aging population, the negative health impacts and costs of the disease will increase dramatically over the next decade.
Although the exact cause of AMD is unknown, genetic studies have implicated the complement system as well as other immune responses in disease pathogenesis and severity.
Furthermore, histologic studies have shown the presence of macrophages, lymphocytes, and mast cells, as well as fibroblasts, in both atrophic lesions and with retinal neovascularization.
This review summarizes discussions from the fifth annual conference of the Arnold and Mabel Beckman Initiative for Macular Research by the Inflammation and Immune Response Task Force.
These deliberations focused on the role of inflammatory immune responses, including complement, inflammasomes, adaptive immune responses, and para-inflammation, unanswered questions and studies to address these questions, and potential immune-related therapeutic targets for AMD.
American Psychological Association (APA)
Whitcup, Scott M.& Sodhi, Akrit& Atkinson, John P.& Holers, V. Michael& Sinha, Debasish& Rohrer, Bärbel…[et al.]. 2013. The Role of the Immune Response in Age-Related Macular Degeneration. International Journal of Inflammation،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-464699
Modern Language Association (MLA)
Whitcup, Scott M.…[et al.]. The Role of the Immune Response in Age-Related Macular Degeneration. International Journal of Inflammation No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-464699
American Medical Association (AMA)
Whitcup, Scott M.& Sodhi, Akrit& Atkinson, John P.& Holers, V. Michael& Sinha, Debasish& Rohrer, Bärbel…[et al.]. The Role of the Immune Response in Age-Related Macular Degeneration. International Journal of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-464699
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464699