Steviol Glycosides Modulate Glucose Transport in Different Cell Types
Joint Authors
Fiorentini, Diana
Prata, Cecilia
Leoncini, Emanuela
Angeloni, Cristina
Vieceli Dalla Sega, Francesco
Hrelia, Silvana
Zambonin, Laura
Rizzo, Benedetta
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Extracts from Stevia rebaudiana Bertoni, a plant native to Central and South America, have been used as a sweetener since ancient times.
Currently, Stevia extracts are largely used as a noncaloric high-potency biosweetener alternative to sugar, due to the growing incidence of type 2 diabetes mellitus, obesity, and metabolic disorders worldwide.
Despite the large number of studies on Stevia and steviol glycosides in vivo, little is reported concerning the cellular and molecular mechanisms underpinning the beneficial effects on human health.
The effect of four commercial Stevia extracts on glucose transport activity was evaluated in HL-60 human leukaemia and in SH-SY5Y human neuroblastoma cells.
The extracts were able to enhance glucose uptake in both cellular lines, as efficiently as insulin.
Our data suggest that steviol glycosides could act by modulating GLUT translocation through the PI3K/Akt pathway since treatments with both insulin and Stevia extracts increased the phosphorylation of PI3K and Akt.
Furthermore, Stevia extracts were able to revert the effect of the reduction of glucose uptake caused by methylglyoxal, an inhibitor of the insulin receptor/PI3K/Akt pathway.
These results corroborate the hypothesis that Stevia extracts could mimic insulin effects modulating PI3K/Akt pathway.
American Psychological Association (APA)
Rizzo, Benedetta& Zambonin, Laura& Angeloni, Cristina& Leoncini, Emanuela& Vieceli Dalla Sega, Francesco& Prata, Cecilia…[et al.]. 2013. Steviol Glycosides Modulate Glucose Transport in Different Cell Types. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-464704
Modern Language Association (MLA)
Rizzo, Benedetta…[et al.]. Steviol Glycosides Modulate Glucose Transport in Different Cell Types. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-464704
American Medical Association (AMA)
Rizzo, Benedetta& Zambonin, Laura& Angeloni, Cristina& Leoncini, Emanuela& Vieceli Dalla Sega, Francesco& Prata, Cecilia…[et al.]. Steviol Glycosides Modulate Glucose Transport in Different Cell Types. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-464704
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464704