Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors for Elderly Patients with Advanced Non-Small Cell Lung Cancer

Joint Authors

Meriggi, F.
Zaniboni, Alberto

Source

Current Gerontology and Geriatrics Research

Issue

Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2010-06-20

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Diseases

Abstract EN

Lung cancer is the leading cause of cancer-related mortality in both men and women and approximately 219,440 new cases of nonsmall cell lung cancer (NSCLC) were estimated to occur in the USA in 2009, which caused 159,390 NSCLC-related deaths.

More than 50% of cases of advanced NSCLC are diagnosed in patients older than age 65, and recent Surveillance Epidemiology and End Results (SEERs) data suggest that the median age at diagnosis is 70 years.

Until recently, the disease has been undertreated in this patient population, with a perception among many clinicians that elderly patients do not tolerate chemotherapy or radiotherapy.

So, single agent chemotherapy is the recommended approach by the ASCO and International Expert Panels in unselected patients.

The introduction of novel targeted therapies, such as Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors (TKIs) which improved survival versus placebo in patients who had previously failed on chemotherapy, gives clinicians new, effective, and better tolerated options to consider when treating NSCLC in elderly patients.

This paper describes the advances of EGFR TKIs for elderly patients with advanced NSCLC.

American Psychological Association (APA)

Meriggi, F.& Zaniboni, Alberto. 2010. Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors for Elderly Patients with Advanced Non-Small Cell Lung Cancer. Current Gerontology and Geriatrics Research،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-464706

Modern Language Association (MLA)

Meriggi, F.& Zaniboni, Alberto. Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors for Elderly Patients with Advanced Non-Small Cell Lung Cancer. Current Gerontology and Geriatrics Research No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-464706

American Medical Association (AMA)

Meriggi, F.& Zaniboni, Alberto. Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors for Elderly Patients with Advanced Non-Small Cell Lung Cancer. Current Gerontology and Geriatrics Research. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-464706

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-464706