Decreased Erythrocyte NA+,K+-ATPase Activity and Increased Plasma TBARS in Prehypertensive Patients
Joint Authors
Pavlak, João Lang
Burgos, Leandro Tibiriçá
Pereira, Ricardo Aparecido
Silva, Luiz Augusto
Malfatti, Carlos Ricardo Maneck
Rieger, Alexandre
Túrmina, Janaína Angela
Rüdger, Cássio Luiz
Osiecki, Raul
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-01
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
The essential hypertension has been associated with membrane cell damage.
The aim of the present study is investigate the relationship between erythrocyte Na+,K+-ATPase and lipoperoxidation in prehypertensive patients compared to normotensive status.
The present study involved the prehypertensive patients (systolic: 136±7 mmHg; diastolic: 86.8±6.3 mmHg; n=8) and healthy men with normal blood pressure (systolic: 110±6.4 mmHg; diastolic: 76.1±4.2 mmHg; n=8) who were matched for age (35±4 years old).
The venous blood samples of antecubital vein (5 mL) were collected into a tube containing sodium heparin as anticoagulant (1000 UI), and erythrocyte ghosts were prepared for quantifying Na+,K+-ATPase activity.
The extent of the thiobarbituric acid reactive substances (TBARS) was determined in plasma.
The statistical analysis was carried out by Student’s t-test and Pearson’s correlation coefficient.
A P<0.05 was considered significant.
The Na+,K+-ATPase activity was lower in prehypertensive patients compared with normotensive subjects (4.9 versus 8.0 nmol Pi/mg protein/min; P<0.05).
The Na+,K+-ATPase activity correlated negatively with TBARS content (r=-0.6; P<0.05) and diastolic blood pressure (r=-0.84; P<0.05).
The present study suggests that Na+,K+-ATPase activity reduction and elevation of the TBARS content may underlie the pathophysiological aspects linked to the prehypertensive status.
American Psychological Association (APA)
Malfatti, Carlos Ricardo Maneck& Burgos, Leandro Tibiriçá& Rieger, Alexandre& Rüdger, Cássio Luiz& Túrmina, Janaína Angela& Pereira, Ricardo Aparecido…[et al.]. 2012. Decreased Erythrocyte NA+,K+-ATPase Activity and Increased Plasma TBARS in Prehypertensive Patients. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-464712
Modern Language Association (MLA)
Malfatti, Carlos Ricardo Maneck…[et al.]. Decreased Erythrocyte NA+,K+-ATPase Activity and Increased Plasma TBARS in Prehypertensive Patients. The Scientific World Journal No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-464712
American Medical Association (AMA)
Malfatti, Carlos Ricardo Maneck& Burgos, Leandro Tibiriçá& Rieger, Alexandre& Rüdger, Cássio Luiz& Túrmina, Janaína Angela& Pereira, Ricardo Aparecido…[et al.]. Decreased Erythrocyte NA+,K+-ATPase Activity and Increased Plasma TBARS in Prehypertensive Patients. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-464712
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464712