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Electrospun Collagen : A Tissue Engineering Scaffold with Unique Functional Properties in a Wide Variety of Applications
Joint Authors
Sell, Scott A.
Jha, Balendu Shekhar
Ayres, Chantal E.
Bowlin, Gary L.
Simpson, David G.
Bowman, James R.
Telemeco, Todd A.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-07
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Engineering Sciences and Information Technology
Chemistry
Civil Engineering
Abstract EN
Type I collagen and gelatin, a derivative of Type I collagen that has been denatured, can each be electrospun into tissue engineering scaffolds composed of nano- to micron-scale diameter fibers.
We characterize the biological activity of these materials in a variety of tissue engineering applications, including endothelial cell-scaffold interactions, the onset of bone mineralization, dermal reconstruction, and the fabrication of skeletal muscle prosthetics.
Electrospun collgen (esC) consistently exhibited unique biological properties in these functional assays.
Even though gelatin can be spun into fibrillar scaffolds that resemble scaffolds of esC, our assays reveal that electrospun gelatin (esG) lacks intact α chains and is composed of proinflammatory peptide fragments.
In contrast, esC retains intact α chains and is enriched in the α 2(I) subunit.
The distinct fundamental properties of the constituent subunits that make up esC and esG appear to define their biological and functional properties.
American Psychological Association (APA)
Jha, Balendu Shekhar& Ayres, Chantal E.& Bowman, James R.& Telemeco, Todd A.& Sell, Scott A.& Bowlin, Gary L.…[et al.]. 2011. Electrospun Collagen : A Tissue Engineering Scaffold with Unique Functional Properties in a Wide Variety of Applications. Journal of Nanomaterials،Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-464718
Modern Language Association (MLA)
Jha, Balendu Shekhar…[et al.]. Electrospun Collagen : A Tissue Engineering Scaffold with Unique Functional Properties in a Wide Variety of Applications. Journal of Nanomaterials No. 2011 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-464718
American Medical Association (AMA)
Jha, Balendu Shekhar& Ayres, Chantal E.& Bowman, James R.& Telemeco, Todd A.& Sell, Scott A.& Bowlin, Gary L.…[et al.]. Electrospun Collagen : A Tissue Engineering Scaffold with Unique Functional Properties in a Wide Variety of Applications. Journal of Nanomaterials. 2011. Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-464718
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464718