Clinical Significance of Amyloid Precursor Protein in Patients with Testicular Germ Cell Tumor
Joint Authors
Ouchi, Yasuyoshi
Fujimura, Tetsuya
Inoue, Satoshi
Takahashi, Satoru
Obinata, Daisuke
Takayama, Kenichi
Urano, Tomohiko
Yamada, Yuta
Murata, Taro
Homma, Yukio
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
The biological role of amyloid precursor protein (APP) is not well understood, especially in testicular germ cell tumors (TGCTs).
Therefore, we aimed to investigate the immunoreactivity (IR) and expression of APP in TGCTs and evaluated its clinical relevance.
Materials and Methods.
We performed an analysis of immunohistochemistry and mRNA expression of APP in 64 testicular specimens and 21 snap-frozen samples obtained from 1985 to 2004.
We then evaluated the association between APP expression and clinicopathological status in TGCTs.
Results.
Positive APP IR was observed in 9.8% (4/41) of seminomatous germ cell tumors (SGCTs) and 39.1% (9/23) of nonseminomatous germ cell tumors (NGCTs).
NGCTs showed significantly more cases of positive IR (P=0.00870) and a higher mRNA expression level compared with those of SGCTs (P=0.0140).
Positive APP IR was also significantly associated with α-fetoprotein (αFP) elevation (P=0.00870) and venous invasion (P=0.0414).
Conclusion.
We observed an elevated APP expression in TGCTs, especially in NGCTs.
APP may be associated with a more aggressive cancer in TGCTs.
American Psychological Association (APA)
Yamada, Yuta& Fujimura, Tetsuya& Takahashi, Satoru& Takayama, Kenichi& Urano, Tomohiko& Murata, Taro…[et al.]. 2013. Clinical Significance of Amyloid Precursor Protein in Patients with Testicular Germ Cell Tumor. Advances in Urology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-464735
Modern Language Association (MLA)
Yamada, Yuta…[et al.]. Clinical Significance of Amyloid Precursor Protein in Patients with Testicular Germ Cell Tumor. Advances in Urology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-464735
American Medical Association (AMA)
Yamada, Yuta& Fujimura, Tetsuya& Takahashi, Satoru& Takayama, Kenichi& Urano, Tomohiko& Murata, Taro…[et al.]. Clinical Significance of Amyloid Precursor Protein in Patients with Testicular Germ Cell Tumor. Advances in Urology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-464735
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464735