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c-Jun-N-Terminal Kinase Signaling Is Involved in Cyclosporine-Induced Epithelial Phenotypic Changes
Joint Authors
Pallet, Nicolas
Anglicheau, Dany
Thervet, Eric
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Tubular epithelial cells play a central role in the pathogenesis of chronic nephropathies.
Previous toxicogenomic studies have demonstrated that cyclosporine- (CsA-) induced epithelial phenotypic changes (EPCs) are reminiscent of an incomplete epithelial to mesenchymal transition (EMT) in a TGF-β-independent manner.
Furthermore, we identified endoplasmic reticulum (ER) stress as a potential mechanism that may participate in the modulation of tubular cell plasticity during CsA exposure.
Because c-jun-N-terminal kinase (JNK), which is activated during ER stress, is implicated in kidney fibrogenesis, we undertook the current study to identify the role of JNK signaling in EPCs induced by CsA.
In primary cultures of human renal epithelial cells, CsA activates JNK signaling, and the treatment with a JNK inhibitor reduces the occurrence of cell shape changes, E-cadherin downregulation, cell migration, and Snail-1 expression.
Our results suggest that CsA activates JNK signaling, which, in turn, may participate in the morphological alterations through the regulation of Snail-1 expression.
American Psychological Association (APA)
Pallet, Nicolas& Thervet, Eric& Anglicheau, Dany. 2011. c-Jun-N-Terminal Kinase Signaling Is Involved in Cyclosporine-Induced Epithelial Phenotypic Changes. Journal of Transplantation،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-464749
Modern Language Association (MLA)
Pallet, Nicolas…[et al.]. c-Jun-N-Terminal Kinase Signaling Is Involved in Cyclosporine-Induced Epithelial Phenotypic Changes. Journal of Transplantation No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-464749
American Medical Association (AMA)
Pallet, Nicolas& Thervet, Eric& Anglicheau, Dany. c-Jun-N-Terminal Kinase Signaling Is Involved in Cyclosporine-Induced Epithelial Phenotypic Changes. Journal of Transplantation. 2011. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-464749
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464749