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Propolis Varnish : Antimicrobial Properties against Cariogenic Bacteria, Cytotoxicity, and Sustained-Release Profile
Joint Authors
Cortes, Maria Esperanza
Grenho, Liliana
Faraco, André Augusto G.
Macedo, Filipe Augusto F. F.
Santos, Vagner Rodrigues
De Luca, Mariana P.
Franca, Juçara R.
Moreira, Allyson N.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Varnishes are preparations that differ in the polymeric matrix and therapeutical agents.
In dentistry they are used to prevent caries.
In this study we developed a propolis varnish, considering propolis properties against cariogenic bacteria.
To a chitosan polymeric base (CHV) was added ethanolic propolis extract in different concentrations: PV1 (5%), PV2 (10%), and PV3 (15%).
Antimicrobial activity was carried out against Streptococcus mutans (SM), Streptococcus sanguinis (SG), Streptococcus salivarius (SS), and Lactobacillus casei (LC) through agar diffusion method.
The three propolis concentrations incorporated were effective in inhibiting the growth of all microorganisms, but without significant difference between the zones of inhibition observed.
Cytotoxicity assay was done by MTT method.
Data were analyzed by one-way ANOVA and Bonferroni test.
None of the varnishes were cytotoxic, keeping 80% of viable cells, while CHV allowed cellular proliferation (120%).
Sustained-release test was carried out by applying 40 μL of each varnish in the buccal surface of bovine teeth and kept in an ethanol/water solution removed in regular times.
According to the “independent model approach,” the release profiles were distinct from each varnish and the most prolonged was PV3 (8 weeks).
Varnish formulations had satisfactory antimicrobial activity against cariogenic bacteria and have a low cytotoxicity (<50%).
American Psychological Association (APA)
De Luca, Mariana P.& Franca, Juçara R.& Macedo, Filipe Augusto F. F.& Grenho, Liliana& Cortes, Maria Esperanza& Faraco, André Augusto G.…[et al.]. 2014. Propolis Varnish : Antimicrobial Properties against Cariogenic Bacteria, Cytotoxicity, and Sustained-Release Profile. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-464757
Modern Language Association (MLA)
De Luca, Mariana P.…[et al.]. Propolis Varnish : Antimicrobial Properties against Cariogenic Bacteria, Cytotoxicity, and Sustained-Release Profile. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-464757
American Medical Association (AMA)
De Luca, Mariana P.& Franca, Juçara R.& Macedo, Filipe Augusto F. F.& Grenho, Liliana& Cortes, Maria Esperanza& Faraco, André Augusto G.…[et al.]. Propolis Varnish : Antimicrobial Properties against Cariogenic Bacteria, Cytotoxicity, and Sustained-Release Profile. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-464757
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464757