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A Metabolic Study on Colon Cancer Using 1H Nuclear Magnetic Resonance Spectroscopy
Joint Authors
Tafazzoli, Mohsen
Arjmand, Mohammad
Sadeghi, Sedigheh
Tashakorpour, Mohammad
Eshaq Hosseini, Seyed Mahmood
Iravani, Ayda
Vahabi, Farideh
Fazeli, Sadegh Mohammad
Oghalayee, Akbar
Mehrabanfar, Mahshid
Haj Hosseini, Reza
Bayat, Parastoo
Zamani, Zahra
Source
Biochemistry Research International
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Colorectal carcinoma is the third cause of cancer deaths in the world.
For diagnosis, invasive methods like colonoscopy and sigmoidoscopy are used, and noninvasive screening tests are not very accurate.
We decided to study the potential of 1HNMR spectroscopy with metabolomics and chemometrics as a preliminary noninvasive test.
We obtained a distinguishing pattern of metabolites and metabolic pathways between colon cancer patient and normal.
Methods.
Sera were obtained from confirmed colon cancer patients and the same number of healthy controls.
Samples were sent for 1HNMR spectroscopy and analysis was carried out Chenomex and MATLAB software.
Metabolites were identified using Human Metabolic Data Base (HDMB) and the main metabolic cycles were identified using Metaboanalyst software.
Results.
15 metabolites were identified such as pyridoxine, orotidine, and taurocholic acid.
Main metabolic cycles involved were the bile acid biosynthesis, vitamin B6 metabolism, methane metabolism, and glutathione metabolism.
Discussion.
The main detected metabolic cycles were also reported earlier in different cancers.
Our observations corroborated earlier studies that suggest the importance of lowering serum LCA/DCA and increasing vitamin B6 intake to help prevent colon cancer.
This work can be looked upon as a preliminary step in using 1HNMR analysis as a screening test before invasive procedures.
American Psychological Association (APA)
Zamani, Zahra& Arjmand, Mohammad& Vahabi, Farideh& Eshaq Hosseini, Seyed Mahmood& Fazeli, Sadegh Mohammad& Iravani, Ayda…[et al.]. 2014. A Metabolic Study on Colon Cancer Using 1H Nuclear Magnetic Resonance Spectroscopy. Biochemistry Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-464764
Modern Language Association (MLA)
Zamani, Zahra…[et al.]. A Metabolic Study on Colon Cancer Using 1H Nuclear Magnetic Resonance Spectroscopy. Biochemistry Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-464764
American Medical Association (AMA)
Zamani, Zahra& Arjmand, Mohammad& Vahabi, Farideh& Eshaq Hosseini, Seyed Mahmood& Fazeli, Sadegh Mohammad& Iravani, Ayda…[et al.]. A Metabolic Study on Colon Cancer Using 1H Nuclear Magnetic Resonance Spectroscopy. Biochemistry Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-464764
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464764