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Effect of Alocasia indica Tuber Extract on Reducing Hepatotoxicity and Liver Apoptosis in Alcohol Intoxicated Rats
Joint Authors
Bhattacharya, Koushik
Mukherjee, Sandip
Pal, Swagata
Khowala, Suman
Mukherjee, Soumya
Bhattacharjee, Ankita
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The possible protective role of ethanolic extract of A.
indica tuber (EEAIT) in hepatotoxicity and apoptosis of liver caused by alcohol in rats was investigated.
Treatment of rats with alcohol (3 g ethanol per kg body weight per day for 15 days intraperitoneally) produced marked elevation of liver biomarkers such as serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyl transpeptidase (γ-GT), and total bilirubin levels which were reduced by EEAIT in a dose-dependent manner.
Furthermore, EEAIT improved antioxidant status (MDA, NO, and GSH) and preserved hepatic cell architecture.
Simultaneous supplementation with EEAIT significantly restored hepatic catalase (CAT) and superoxide dismutase (SOD) activity levels towards normal.
The studies with biochemical markers were strongly supported by the histopathological evaluation of the liver tissue.
EEAIT also attenuated apoptosis and necrosis features of liver cell found in immunohistochemical evaluation.
HPLC analysis of the extract showed the presence of three major peaks of which peak 2 (RT: 33.33 min) contains the highest area (%) and UV spectrum analysis identified it as flavonoids.
It is therefore suggested that EEAIT can provide a definite protective effect against chronic hepatic injury caused by alcohol in rats, which may mainly be associated with its antioxidative effect.
American Psychological Association (APA)
Pal, Swagata& Bhattacharjee, Ankita& Mukherjee, Sandip& Bhattacharya, Koushik& Mukherjee, Soumya& Khowala, Suman. 2014. Effect of Alocasia indica Tuber Extract on Reducing Hepatotoxicity and Liver Apoptosis in Alcohol Intoxicated Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-464795
Modern Language Association (MLA)
Pal, Swagata…[et al.]. Effect of Alocasia indica Tuber Extract on Reducing Hepatotoxicity and Liver Apoptosis in Alcohol Intoxicated Rats. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-464795
American Medical Association (AMA)
Pal, Swagata& Bhattacharjee, Ankita& Mukherjee, Sandip& Bhattacharya, Koushik& Mukherjee, Soumya& Khowala, Suman. Effect of Alocasia indica Tuber Extract on Reducing Hepatotoxicity and Liver Apoptosis in Alcohol Intoxicated Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-464795
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464795