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Prognostic and Therapeutic Potential of Nuclear Receptors in Head and Neck Squamous Cell Carcinomas
Author
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-09-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Head and neck squamous cell carcinomas are among the most common neoplasms worldwide and characterized by local tumor aggressiveness, high rate of early recurrences, development of metastasis, and second primary cancers.
Despite modern therapeutic strategies and sophisticated surgical management, overall survival-rates remained largely unchanged over the last decades.
Thus, the need for novel treatment options for this tumor entity is undeniable.
A key event in carcinogenesis is the uncontrolled modulation of genetic programs.
Nuclear receptors belong to a large superfamily of transcription factors implicated in a broad spectrum of physiological and pathophysiological processes, including cancer.
Several nuclear receptors have also been associated with head and neck cancer.
This review will summarize their mode of action, prognostic/therapeutic relevance, as well as preclinical and clinical studies currently targeting nuclear receptors in this tumor entity.
American Psychological Association (APA)
Knauer, Shirley K.. 2009. Prognostic and Therapeutic Potential of Nuclear Receptors in Head and Neck Squamous Cell Carcinomas. Journal of Oncology،Vol. 2009, no. 2009, pp.1-10.
https://search.emarefa.net/detail/BIM-464807
Modern Language Association (MLA)
Knauer, Shirley K.. Prognostic and Therapeutic Potential of Nuclear Receptors in Head and Neck Squamous Cell Carcinomas. Journal of Oncology No. 2009 (2009), pp.1-10.
https://search.emarefa.net/detail/BIM-464807
American Medical Association (AMA)
Knauer, Shirley K.. Prognostic and Therapeutic Potential of Nuclear Receptors in Head and Neck Squamous Cell Carcinomas. Journal of Oncology. 2009. Vol. 2009, no. 2009, pp.1-10.
https://search.emarefa.net/detail/BIM-464807
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464807