Invasive Mold Infections : Virulence and Pathogenesis of Mucorales
Joint Authors
Source
International Journal of Microbiology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-01
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Abstract EN
Mucorales have been increasingly reported as cause of invasive fungal infections in immunocompromised subjects, particularly in patients with haematological malignancies or uncontrolled diabetes mellitus and in those under deferoxamine treatment or undergoing dialysis.
The disease often leads to a fatal outcome, but the pathogenesis of the infection is still poorly understood as well as the role of specific virulence determinants and the interaction with the host immune system.
Members of the order Mucorales are responsible of almost all cases of invasive mucormycoses, the majority of the etiological agents belonging to the Mucoraceae family.
Mucorales are able to produce various proteins and metabolic products toxic to animals and humans, but the pathogenic role of these potential virulence factors is unknown.
The availability of free iron in plasma and tissues is believed to be crucial for the pathogenesis of these mycoses.
Vascular invasion and neurotropism are considered common pathogenic features of invasive mucormycoses.
American Psychological Association (APA)
Morace, Giulia& Borghi, Elisa. 2011. Invasive Mold Infections : Virulence and Pathogenesis of Mucorales. International Journal of Microbiology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-464815
Modern Language Association (MLA)
Morace, Giulia& Borghi, Elisa. Invasive Mold Infections : Virulence and Pathogenesis of Mucorales. International Journal of Microbiology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-464815
American Medical Association (AMA)
Morace, Giulia& Borghi, Elisa. Invasive Mold Infections : Virulence and Pathogenesis of Mucorales. International Journal of Microbiology. 2011. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-464815
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464815