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Nicotine Exposure Exacerbates Development of Cataracts in a Type 1 Diabetic Rat Model
Joint Authors
Motamedi, Massoud
Kulp, Gabriela A.
Tirgan, Nima
Gupta, Praveena
Tilton, Ronald G.
Wiraszka, Tomasz A.
Godley, Bernard
Boretsky, Adam
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Diabetes and smoking are known risk factors for cataract development.
In this study, we evaluated the effect of nicotine on the progression of cataracts in a type 1 diabetic rat model.
Diabetes was induced in Sprague-Dawley rats by a single injection of 65 mg/kg streptozotocin.
Daily nicotine injections were administered subcutaneously.
Forty-five rats were divided into groups of diabetics with and without nicotine treatment and controls with and without nicotine treatment.
Progression of lens opacity was monitored using a slit lamp biomicroscope and scores were assigned.
To assess whether systemic inflammation played a role in mediating cataractogenesis, we studied serum levels of eotaxin, IL-6, and IL-4.
The levels of the measured cytokines increased significantly in nicotine-treated and untreated diabetic animals versus controls and demonstrated a positive trend in the nicotine-treated diabetic rats.
Our data suggest the presence of a synergistic relationship between nicotine and diabetes that accelerated cataract formation via inflammatory mediators.
American Psychological Association (APA)
Tirgan, Nima& Kulp, Gabriela A.& Gupta, Praveena& Boretsky, Adam& Wiraszka, Tomasz A.& Godley, Bernard…[et al.]. 2012. Nicotine Exposure Exacerbates Development of Cataracts in a Type 1 Diabetic Rat Model. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-464821
Modern Language Association (MLA)
Tirgan, Nima…[et al.]. Nicotine Exposure Exacerbates Development of Cataracts in a Type 1 Diabetic Rat Model. Experimental Diabetes Research No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-464821
American Medical Association (AMA)
Tirgan, Nima& Kulp, Gabriela A.& Gupta, Praveena& Boretsky, Adam& Wiraszka, Tomasz A.& Godley, Bernard…[et al.]. Nicotine Exposure Exacerbates Development of Cataracts in a Type 1 Diabetic Rat Model. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-464821
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464821