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A Retrospective Review of the Use of Regional Citrate Anticoagulation in Continuous Venovenous Hemofiltration for Critically Ill Patients
Joint Authors
Lai, Kang Yiu
Shum, Hoi-Ping
Leung, Anne Kit-Hung
Chan, King-Chung
Chan, Stanley Choi-Hung
Yan, Wing-Wa
Source
Critical Care Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
The emergence of a commercially prepared citrate solution has revolutionized the use of RCA in the intensive care unit (ICU).
The aim of this study was to evaluate the safety profile of a commercially prepared citrate solution.
Method.
Predilution continuous venovenous hemofiltration (CVVH) was performed using Prismocitrate 10/2 at 2500 mL/h and a blood flow rate of 150 mL/min.
Calcium chloride solution was infused to maintain ionized calcium within 1.0–1.2 mmol/L.
An 8.4% sodium bicarbonate solution was infused separately.
Treatment was stopped when the predefined clinical target was reached or the filter clotted.
Result.
58 sessions of citrate RCA were analyzed.
The median circuit lifetime was 26.0 h (interquartile range IQR 21.2–44.3).
The percentage of circuits lasting more than 12 h, 24 h, and 48 h was 94.6%, 58.9%, and 16.1%, respectively.
There was no incidence of hypernatremia and median pH was <7.5.
Hypomagnesemia and hypophosphatemia were detected in 41.6% and 17.6% of blood samples taken, respectively.
Although 16 episodes had a total calcium/ionized calcium (total Ca/iCa) >2.5, only four patients had evidence of citrate accumulation.
Conclusion.
The commercially prepared citrate solution could be used safely in critically ill patients who required CVVH with no major adverse events.
American Psychological Association (APA)
Leung, Anne Kit-Hung& Shum, Hoi-Ping& Chan, King-Chung& Chan, Stanley Choi-Hung& Lai, Kang Yiu& Yan, Wing-Wa. 2013. A Retrospective Review of the Use of Regional Citrate Anticoagulation in Continuous Venovenous Hemofiltration for Critically Ill Patients. Critical Care Research and Practice،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-464840
Modern Language Association (MLA)
Leung, Anne Kit-Hung…[et al.]. A Retrospective Review of the Use of Regional Citrate Anticoagulation in Continuous Venovenous Hemofiltration for Critically Ill Patients. Critical Care Research and Practice No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-464840
American Medical Association (AMA)
Leung, Anne Kit-Hung& Shum, Hoi-Ping& Chan, King-Chung& Chan, Stanley Choi-Hung& Lai, Kang Yiu& Yan, Wing-Wa. A Retrospective Review of the Use of Regional Citrate Anticoagulation in Continuous Venovenous Hemofiltration for Critically Ill Patients. Critical Care Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-464840
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464840