Impact of Adiponectin Overexpression on Allergic Airways Responses in Mice
Joint Authors
Shore, Stephanie A.
Williams, Alison S.
Wurmbrand, Allison P.
Verbout, Norah G.
Hug, Christopher
Halayko, Andrew J.
Benedito, Leandro
Kasahara, David I.
Si, Huiqing
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-04
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Obesity is an important risk factor for asthma.
Obese individuals have decreased circulating adiponectin, an adipose-derived hormone with anti-inflammatory properties.
We hypothesized that transgenic overexpression of adiponectin would attenuate allergic airways inflammation and mucous hyperplasia in mice.
To test this hypothesis, we used mice overexpressing adiponectin (Adipo Tg).
Adipo Tg mice had marked increases in both serum adiponectin and bronchoalveolar lavage (BAL) fluid adiponectin.
Both acute and chronic ovalbumin (OVA) sensitization and challenge protocols were used.
In both protocols, OVA-induced increases in total BAL cells were attenuated in Adipo Tg versus WT mice.
In the acute protocol, OVA-induced increases in several IL-13 dependent genes were attenuated in Adipo Tg versus WT mice, even though IL-13 per se was not affected.
With chronic exposure, though OVA-induced increases in goblet cells numbers per millimeter of basement membrane were greater in Adipo Tg versus WT mice, mRNA abundance of mucous genes in lungs was not different.
Also, adiponectin overexpression did not induce M2 polarization in alveolar macrophages.
Our results indicate that adiponectin protects against allergen-induced inflammatory cell recruitment to the airspaces, but not development of goblet cell hyperplasia.
American Psychological Association (APA)
Verbout, Norah G.& Benedito, Leandro& Williams, Alison S.& Kasahara, David I.& Wurmbrand, Allison P.& Si, Huiqing…[et al.]. 2013. Impact of Adiponectin Overexpression on Allergic Airways Responses in Mice. Journal of Allergy،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-464843
Modern Language Association (MLA)
Verbout, Norah G.…[et al.]. Impact of Adiponectin Overexpression on Allergic Airways Responses in Mice. Journal of Allergy No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-464843
American Medical Association (AMA)
Verbout, Norah G.& Benedito, Leandro& Williams, Alison S.& Kasahara, David I.& Wurmbrand, Allison P.& Si, Huiqing…[et al.]. Impact of Adiponectin Overexpression on Allergic Airways Responses in Mice. Journal of Allergy. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-464843
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464843