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Possible Implication of Local Immune Response in Darier's Disease : An Immunohistochemical Characterization of Lesional Inflammatory Infiltrate
Joint Authors
Miracco, Clelia
Mourmouras, Vasileios
Cantarini, Luca
Mastrogiulio, Maria Grazia
Pietronudo, Francesco
Luzi, Pietro
Pellegrino, Michele
Onorati, Monica
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cell-mediated immunity is considered to be normal in Darier's Disease (DD), an inherited skin disorder complicated by skin infections.
To date, there are no investigations on the local inflammatory infiltrate in DD skin lesions.
In this immunohistochemical study we characterized and quantified it, making comparisons with two other inflammatory skin disorders, that is, pemphigus vulgaris (PV) and lichen ruber planus (LRP), and with the normal skin (NSk).
We found a significant (P<.05) decrease of CD1a+ Langerhans cells (LCs) in DD, compared to PV, LRP, and NSk, and of CD123+ plasmacytoid dendritic cells (pDCs), compared to PV and LRP.
We hypothesize that the genetic damage of keratinocytes might result in a loss of some subsets of dendritic cells and, consequently, in an impaired local immune response, which might worsen the infections that inevitably occur in this disease.
American Psychological Association (APA)
Miracco, Clelia& Pietronudo, Francesco& Mourmouras, Vasileios& Pellegrino, Michele& Onorati, Monica& Mastrogiulio, Maria Grazia…[et al.]. 2010. Possible Implication of Local Immune Response in Darier's Disease : An Immunohistochemical Characterization of Lesional Inflammatory Infiltrate. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-464894
Modern Language Association (MLA)
Miracco, Clelia…[et al.]. Possible Implication of Local Immune Response in Darier's Disease : An Immunohistochemical Characterization of Lesional Inflammatory Infiltrate. Mediators of Inflammation No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-464894
American Medical Association (AMA)
Miracco, Clelia& Pietronudo, Francesco& Mourmouras, Vasileios& Pellegrino, Michele& Onorati, Monica& Mastrogiulio, Maria Grazia…[et al.]. Possible Implication of Local Immune Response in Darier's Disease : An Immunohistochemical Characterization of Lesional Inflammatory Infiltrate. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-464894
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464894