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Clinicopathological Features and Management of Cancers in Lynch Syndrome
Author
Source
Pathology Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Lynch syndrome (LS) is characterized by an autosomal dominant inheritance of the early onset of colorectal cancer (CRC) and endometrial cancer, as well as increased risk for several other cancers including gastric, urinary tract, ovarian, small bowel, biliary tract, and brain tumors.
The syndrome is due to a mutation in one of the four DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, or PMS2.
The majority of LS patients and families can now be identified, and the underlying mutation detected using genetic diagnostics.
Regular surveillance for CRC and endometrial cancer has proved beneficial for mutation carriers.
However, screening for other tumors is also recommended even though experiences in the screening of these tumors is limited.
Prophylactic colectomy, prophylactic hysterectomy, and bilateral salpingo-oophorectomy may be reasonable options for selected patients with LS.
This paper describes the features and management of LS.
American Psychological Association (APA)
Aarnio, Markku. 2012. Clinicopathological Features and Management of Cancers in Lynch Syndrome. Pathology Research International،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-464895
Modern Language Association (MLA)
Aarnio, Markku. Clinicopathological Features and Management of Cancers in Lynch Syndrome. Pathology Research International No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-464895
American Medical Association (AMA)
Aarnio, Markku. Clinicopathological Features and Management of Cancers in Lynch Syndrome. Pathology Research International. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-464895
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464895