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From DNA Radiation Damage to Cell Death : Theoretical Approaches
Author
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Some representative models of radiation-induced cell death, which is a crucial endpoint in radiobiology, were reviewed.
The basic assumptions were identified, their consequences on predicted cell survival were analyzed, and the advantages and drawbacks of each approach were outlined.
In addition to “historical” approaches such as the Target Theory, the Linear-Quadratic model, the Theory of Dual Radiation Action and Katz' model, the more recent Local Effect Model was discussed, focusing on its application in Carbon-ion hadrontherapy.
Furthermore, a mechanistic model developed at the University of Pavia and based on the relationship between cell inactivation and chromosome aberrations was presented, together with recent results; the good agreement between model predictions and literature experimental data on different radiation types (photons, protons, alpha particles, and Carbon ions) supported the idea that asymmetric chromosome aberrations like dicentrics and rings play a fundamental role for cell death.
Basing on these results, a reinterpretation of the TDRA was also proposed, identifying the TDRA “sublesions” and “lesions” as clustered DNA double-strand breaks and (lethal) chromosome aberrations, respectively.
American Psychological Association (APA)
Ballarini, Francesca. 2010. From DNA Radiation Damage to Cell Death : Theoretical Approaches. Journal of Nucleic Acids،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-464926
Modern Language Association (MLA)
Ballarini, Francesca. From DNA Radiation Damage to Cell Death : Theoretical Approaches. Journal of Nucleic Acids No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-464926
American Medical Association (AMA)
Ballarini, Francesca. From DNA Radiation Damage to Cell Death : Theoretical Approaches. Journal of Nucleic Acids. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-464926
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464926