Persistence of Th17Tc17 Cell Expression upon Smoking Cessation in Mice with Cigarette Smoke-Induced Emphysema
Joint Authors
Huang, Ying
Zhong, Xiao-Ning
Tang, Hai-Juan
Duan, Min-Chao
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Th17 and Tc17 cells may be involved in the pathogenesis of chronic obstructive pulmonary disease (COPD), a disease caused predominantly by cigarette smoking.
Smoking cessation is the only intervention in the management of COPD.
However, even after cessation, the airway inflammation may be present.
In the current study, mice were exposed to room air or cigarette smoke for 24 weeks or 24 weeks followed by 12 weeks of cessation.
Morphological changes were evaluated by mean linear intercepts (Lm) and destructive index (DI).
The frequencies of CD8+IL-17+(Tc17) and CD4+IL-17+(Th17) cells, the mRNA levels of ROR gamma and IL-17, and the levels of IL-8, TNF-alpha, and IFN-gamma in lungs or bronchoalveolar lavage fluid of mice were assayed.
Here we demonstrated that alveolar enlargement and destruction induced by cigarette smoke exposure were irreversible and that cigarette smokeenhanced these T-cell subsets, and related cytokines were not significantly reduced after smoking cessation.
In addition, the frequencies of Th17 and Tc17 cells in lungs of smoke-exposed mice and cessation mice were positively correlated with emphysematous lesions.
More important, the frequencies of Tc17 cells were much higher than Th17 cells, and there was a significantly positive correlation between Th17 and Tc17.
These results suggested that Th17/Tc17 infiltration in lungs may play a critical role in sustaining lung inflammation in emphysema.
Blocking the abnormally increased numbers of Tc17 and Th17 cells may be a reasonable therapeutic strategy for emphysema.
American Psychological Association (APA)
Duan, Min-Chao& Tang, Hai-Juan& Zhong, Xiao-Ning& Huang, Ying. 2013. Persistence of Th17Tc17 Cell Expression upon Smoking Cessation in Mice with Cigarette Smoke-Induced Emphysema. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-464935
Modern Language Association (MLA)
Duan, Min-Chao…[et al.]. Persistence of Th17Tc17 Cell Expression upon Smoking Cessation in Mice with Cigarette Smoke-Induced Emphysema. Clinical and Developmental Immunology No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-464935
American Medical Association (AMA)
Duan, Min-Chao& Tang, Hai-Juan& Zhong, Xiao-Ning& Huang, Ying. Persistence of Th17Tc17 Cell Expression upon Smoking Cessation in Mice with Cigarette Smoke-Induced Emphysema. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-464935
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464935