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Rottlerin and Cancer : Novel Evidence and Mechanisms
Joint Authors
Maioli, Emanuela
Torricelli, C.
Giuseppe, Valacchi
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Because cancers are caused by deregulation of hundreds of genes, an ideal anticancer agent should target multiple gene products or signaling pathways simultaneously.
Recently, extensive research has addressed the chemotherapeutic potential of plant-derived compounds.
Among the ever-increasing list of naturally occurring anticancer agents, Rottlerin appears to have great potentiality for being used in chemotherapy because it affects several cell machineries involved in survival, apoptosis, autophagy, and invasion.
The underlying mechanisms that have been described are diverse, and the final, cell-specific, Rottlerin outcome appears to result from a combination of signaling pathways at multiple levels.
This paper seeks to summarize the multifocal signal modulatory properties of Rottlerin, which merit to be further exploited for successful prevention and treatment of cancer.
American Psychological Association (APA)
Maioli, Emanuela& Torricelli, C.& Giuseppe, Valacchi. 2012. Rottlerin and Cancer : Novel Evidence and Mechanisms. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-464950
Modern Language Association (MLA)
Maioli, Emanuela…[et al.]. Rottlerin and Cancer : Novel Evidence and Mechanisms. The Scientific World Journal No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-464950
American Medical Association (AMA)
Maioli, Emanuela& Torricelli, C.& Giuseppe, Valacchi. Rottlerin and Cancer : Novel Evidence and Mechanisms. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-464950
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464950