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Porphyromonas gingivalis Fimbria-Induced Expression of Inflammatory Cytokines and Cyclooxygenase-2 in Mouse Macrophages and Its Inhibition by the Bioactive Compounds Fibronectin and Melatonin
Joint Authors
Murakami, Yukio
Machino, Mamoru
Fujisawa, Seiichiro
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Porphyromonas gingivalis (Pg) fimbriae, in addition to lipopolysaccharide, are involved in the pathogenesis of periodontal disease.
At the same time, bioactive compounds such as fibronectin (FN) and melatonin in saliva and gingival crevicular fluid have been reported to exert a preventive effect against periodontitis.
Here, we review current knowledge regarding the potent inhibitory effects of FN and melatonin against Pg fimbria-induced induction of proinflammatory cytokines, cyclooxygenase-2 (COX-2) expression, and NF-kappa B activation in mouse macrophages and discuss their possible clinical application for prevention of periodontal diseases induced by oral bacteria.
American Psychological Association (APA)
Murakami, Yukio& Machino, Mamoru& Fujisawa, Seiichiro. 2012. Porphyromonas gingivalis Fimbria-Induced Expression of Inflammatory Cytokines and Cyclooxygenase-2 in Mouse Macrophages and Its Inhibition by the Bioactive Compounds Fibronectin and Melatonin. ISRN Dentistry،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-464956
Modern Language Association (MLA)
Murakami, Yukio…[et al.]. Porphyromonas gingivalis Fimbria-Induced Expression of Inflammatory Cytokines and Cyclooxygenase-2 in Mouse Macrophages and Its Inhibition by the Bioactive Compounds Fibronectin and Melatonin. ISRN Dentistry No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-464956
American Medical Association (AMA)
Murakami, Yukio& Machino, Mamoru& Fujisawa, Seiichiro. Porphyromonas gingivalis Fimbria-Induced Expression of Inflammatory Cytokines and Cyclooxygenase-2 in Mouse Macrophages and Its Inhibition by the Bioactive Compounds Fibronectin and Melatonin. ISRN Dentistry. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-464956
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464956