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Targeting Oncogene-Induced Autophagy : A New Approach in Cancer Therapy?
Joint Authors
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Autophagy is a tightly controlled self-degradation process utilised by cells to sustain cellular homeostasis and to support cell survival in response to metabolic stress and starvation.
Thus, autophagy plays a critical role in promoting cell integrity and maintaining proper function of cellular processes.
Defects in autophagy, however, can have drastic implications in human health and diseases, including cancer.
Described as a double-edged sword in the context of cancer, autophagy can act as both suppressor and facilitator of tumorigenesis.
As such, defining the precise role of autophagy in a multistep event like cancer progression can be complex.
Recent findings have implicated a role for components of the autophagy pathway in oncogene-mediated cell transformation, tumour growth, and survival.
Notably, aggressive cancers driven by Ras oncoproteins rely on autophagy to sustain a reprogrammed mitochondrial metabolic signature and evade cell death.
In this review, we summarize our current understanding of the role of oncogene-induced autophagy in cancer progression and discuss how modulators of autophagic responses can bring about therapeutic benefit and eradication of a subset of cancers that are addicted to this ancient recycling machinery.
American Psychological Association (APA)
Zhang, Fuquan& Cheong, Jit Kong. 2013. Targeting Oncogene-Induced Autophagy : A New Approach in Cancer Therapy?. Journal of Cancer Research،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-464957
Modern Language Association (MLA)
Zhang, Fuquan& Cheong, Jit Kong. Targeting Oncogene-Induced Autophagy : A New Approach in Cancer Therapy?. Journal of Cancer Research No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-464957
American Medical Association (AMA)
Zhang, Fuquan& Cheong, Jit Kong. Targeting Oncogene-Induced Autophagy : A New Approach in Cancer Therapy?. Journal of Cancer Research. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-464957
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464957