Vasorelaxant Effect of Osterici Radix Ethanol Extract on Rat Aortic Rings
Joint Authors
Choi, Ho-Young
Park, Geunyong
Lee, Mihwa
Bu, Youngmin
Ham, Inhye
Kim, Hocheol
Yang, Gabsik
Lee, Kyungjin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The root of Ostericum koreanum Maximowicz has been used as a traditional medicine called “Kanghwal” in Korea (or “Qianghuo” in China).
The purpose of this study was to investigate the vasorelaxant activity and mechanism of action of an ethanol extract of the O.
koreanum root (EOK).
We used isolated rat aortic rings to assess the effects of EOK on various vasorelaxant or vasoconstriction factors.
EOK induced vasorelaxation in phenylephrine hydrochloride (PE) or KCl precontracted aortic rings in a concentration-dependent manner.
However, the vasorelaxant effects of EOK on endothelium-intact aortic rings were reduced by pretreatment with L-NAME or methylene blue.
In Ca2+-free Krebs-Henseleit solution, pretreatment with EOK (0.3 mg/mL) completely inhibited PE-induced constriction.
In addition, EOK (0.3 mg/mL) also completely inhibited vasoconstriction induced by supplemental Ca2+ in aortic rings that were precontracted with PE or KCl.
Furthermore, the EOK-induced vasorelaxation in PE-contracted aortic rings was inhibited by preincubation with nifedipine.
These results indicate that the vasorelaxant effects of EOK are responsible for the induction of NO formation from L-Arg and NO-cGMP pathways, blockage of the extracellular Ca2+ entry via the receptor-operative Ca2+ channel and voltage-dependent calcium channel, and blockage of sarcoplasmic reticulum Ca2+ release via the inositol triphosphate pathway.
American Psychological Association (APA)
Lee, Kyungjin& Park, Geunyong& Ham, Inhye& Yang, Gabsik& Lee, Mihwa& Bu, Youngmin…[et al.]. 2013. Vasorelaxant Effect of Osterici Radix Ethanol Extract on Rat Aortic Rings. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-464969
Modern Language Association (MLA)
Lee, Kyungjin…[et al.]. Vasorelaxant Effect of Osterici Radix Ethanol Extract on Rat Aortic Rings. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-464969
American Medical Association (AMA)
Lee, Kyungjin& Park, Geunyong& Ham, Inhye& Yang, Gabsik& Lee, Mihwa& Bu, Youngmin…[et al.]. Vasorelaxant Effect of Osterici Radix Ethanol Extract on Rat Aortic Rings. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-464969
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464969