Interleukin-1β Expression Is Required for Lysophosphatidic Acid-Induced Lymphangiogenesis in Human Umbilical Vein Endothelial Cells
Joint Authors
Lee, Hsinyu
Lu, JenHer
Lin, Chih-Hsin
Source
International Journal of Inflammation
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Lysophosphatidic acid (LPA) is a lipid mediator which binds to G-protein-coupled receptors and regulates various cellular responses, including inflammation of endothelial cells.
Interleukin- (IL-) 1β, a proinflammatory cytokine, is elevated upon LPA treatment in human umbilical vein endothelial cells (HUVECs).
Previous studies indicated that LPA upregulates vascular endothelial growth factor- (VEGF-) C and lymphatic marker expressions in HUVECs.
However, the relationships between LPA-induced VEGF-C and IL-1β expressions are not clear.
In this paper, we demonstrated that, in the presence of AF12198, an inhibitor of the IL-1 receptor abolished LPA-induced VEGF-C and lymphatic marker expressions in HUVECs.
Furthermore, LPA-induced in vitro tube formation of HUVECs was also suppressed by pretreatment with AF12198.
Our results suggest that LPA-stimulated lymphangiogenesis in HUVECs is mediated through IL-1β-induced VEGF-C expression.
American Psychological Association (APA)
Lin, Chih-Hsin& Lu, JenHer& Lee, Hsinyu. 2010. Interleukin-1β Expression Is Required for Lysophosphatidic Acid-Induced Lymphangiogenesis in Human Umbilical Vein Endothelial Cells. International Journal of Inflammation،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-464970
Modern Language Association (MLA)
Lin, Chih-Hsin…[et al.]. Interleukin-1β Expression Is Required for Lysophosphatidic Acid-Induced Lymphangiogenesis in Human Umbilical Vein Endothelial Cells. International Journal of Inflammation No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-464970
American Medical Association (AMA)
Lin, Chih-Hsin& Lu, JenHer& Lee, Hsinyu. Interleukin-1β Expression Is Required for Lysophosphatidic Acid-Induced Lymphangiogenesis in Human Umbilical Vein Endothelial Cells. International Journal of Inflammation. 2010. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-464970
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464970