Serial Assessment of Cardiac Function during and following Mitoxantrone Infusion in 30 Consecutive Patients with Multiple Sclerosis
Joint Authors
Hellmich, Martin
Haus, Angelika
Franzen, Damian
Source
Multiple Sclerosis International
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-01
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Immunosuppressive therapy is an established therapeutic option in patients suffering from multiple sclerosis (MS).
In an open nonrandomized study we serially assessed cardiac function in 30 consecutive patients with MS before, during, and after mitoxantrone therapy.
Mitoxantrone (12 mg/m2) was administered intravenously at 3-month intervals.
Before each infusion, cardiac function was assessed by history taking, resting electrocardiogram, and echocardiography.
Whereas no patient experienced clinical signs of heart failure, left ventricular pump function decreased continuously during mitoxantrone therapy and did not recover after cessation.
The presented data suggest a dose-dependent and long-lasting toxic cardiac effect of low-dose mitoxantrone therapy in MS.
American Psychological Association (APA)
Franzen, Damian& Haus, Angelika& Hellmich, Martin. 2010. Serial Assessment of Cardiac Function during and following Mitoxantrone Infusion in 30 Consecutive Patients with Multiple Sclerosis. Multiple Sclerosis International،Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-464975
Modern Language Association (MLA)
Franzen, Damian…[et al.]. Serial Assessment of Cardiac Function during and following Mitoxantrone Infusion in 30 Consecutive Patients with Multiple Sclerosis. Multiple Sclerosis International No. 2010 (2010), pp.1-4.
https://search.emarefa.net/detail/BIM-464975
American Medical Association (AMA)
Franzen, Damian& Haus, Angelika& Hellmich, Martin. Serial Assessment of Cardiac Function during and following Mitoxantrone Infusion in 30 Consecutive Patients with Multiple Sclerosis. Multiple Sclerosis International. 2010. Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-464975
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464975