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Matricellular Proteins : A Sticky Affair with Cancers
Joint Authors
Tan, Nguan Soon
Chong, Han Chung
Tan, Chek Kun
Huang, Royston-Luke
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-09
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The multistep process of metastasis is a major hallmark of cancer progression involving the cointeraction and coevolution of the tumor and its microenvironment.
In the tumor microenvironment, tumor cells and the surrounding stromal cells aberrantly secrete matricellular proteins, which are a family of nonstructural proteins in the extracellular matrix (ECM) that exert regulatory roles via a variety of molecular mechanisms.
Matricellular proteins provide signals that support tumorigenic activities characteristic of the metastastic cascade such as epithelial-to-mesenchymal (EMT) transition, angiogenesis, tumor cell motility, proliferation, invasion, evasion from immune surveillance, and survival of anoikis.
Herein, we review the current understanding of the following matricellular proteins and highlight their pivotal and multifacted roles in metastatic progression: angiopoietin-like protein 4 (ANGPTL4), CCN family members cysteine-rich angiogenic inducer 61 (Cyr61/CCN1) and CCN6, osteopontin (OPN), secreted protein acidic and rich in cysteine (SPARC), tenascin C (TNC), and thrombospondin-1 and -2 (TSP1, TSP2).
Insights into the signaling mechanisms resulting from the interaction of these matricellular proteins and their respective molecular partner(s), as well as their subsequent contribution to tumor metastasis, are discussed.
In addition, emerging evidences of their promising potential as therapeutic options and/or targets in the treatment of cancer are also highlighted.
American Psychological Association (APA)
Chong, Han Chung& Tan, Chek Kun& Huang, Royston-Luke& Tan, Nguan Soon. 2012. Matricellular Proteins : A Sticky Affair with Cancers. Journal of Oncology،Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-464985
Modern Language Association (MLA)
Chong, Han Chung…[et al.]. Matricellular Proteins : A Sticky Affair with Cancers. Journal of Oncology No. 2012 (2012), pp.1-17.
https://search.emarefa.net/detail/BIM-464985
American Medical Association (AMA)
Chong, Han Chung& Tan, Chek Kun& Huang, Royston-Luke& Tan, Nguan Soon. Matricellular Proteins : A Sticky Affair with Cancers. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-464985
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464985