Diagnosis of Severe Fetal Anemia Based on Perinatal Outcomes : A Comparative Analysis of the Current Reference Values
Joint Authors
Coelho, Tiago Lanfernini Ricardo
Rezende, Cezar Alencar De Lima
Leite, Henrique Vítor
Reis, Zilma Silveira Nogueira
Osanan, Gabriel Costa
Cabral, Antônio Carlos Vieira
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
To compare current criteria for severe fetal anemia diagnosis.
Methodology.
A cohort study analyzed 105 alloimmunized fetuses that underwent cordocentesis due to risk of anemia.
Concordance among the diagnostic criteria for severe fetal anemia, hemoglobin deficit >7 g/dL, hemoglobin deficit ≥5 g/dL, and hemoglobin concentration <0.55 MoM, was analyzed using Cohen’s Kappa index.
Perinatal mortality, fetal hydrops, and fetal acidosis were used to discuss discordances.
Results.
There was fair concordance among the three criteria analyzed: 0.80 (Kappa index, IC 95%: 0.67 to 0.93) when comparing hemoglobin deficit >7.0 g/dL and hemoglobin concentration <0.55 MoM criteria, 0.63 (Kappa index, IC 95%: 0.47 to 0.69) when comparing hemoglobin deficit ≥5.0 g/dL and hemoglobin deficit >7.0 g/dL reference, and 0.77 (Kappa index, IC 95%: 0.64 to 0.90) when comparing hemoglobin deficit≥5.0 g/dL and hemoglobin concentration <0.55 MoM standards.
Eighteen cases were classified differently depending on the criteria used.
The cut-off point of hemoglobin deficit ≥5 g/dL was the best criterion to discriminate fetuses with poor perinatal outcome in our study.
Conclusions.
Relevant discordances in classification of severe fetal anemia were pointed out.
Some criteria may underestimate the real gravity of fetal anemia.
American Psychological Association (APA)
Reis, Zilma Silveira Nogueira& Osanan, Gabriel Costa& Coelho, Tiago Lanfernini Ricardo& Rezende, Cezar Alencar De Lima& Leite, Henrique Vítor& Cabral, Antônio Carlos Vieira. 2013. Diagnosis of Severe Fetal Anemia Based on Perinatal Outcomes : A Comparative Analysis of the Current Reference Values. Anemia،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-464996
Modern Language Association (MLA)
Reis, Zilma Silveira Nogueira…[et al.]. Diagnosis of Severe Fetal Anemia Based on Perinatal Outcomes : A Comparative Analysis of the Current Reference Values. Anemia No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-464996
American Medical Association (AMA)
Reis, Zilma Silveira Nogueira& Osanan, Gabriel Costa& Coelho, Tiago Lanfernini Ricardo& Rezende, Cezar Alencar De Lima& Leite, Henrique Vítor& Cabral, Antônio Carlos Vieira. Diagnosis of Severe Fetal Anemia Based on Perinatal Outcomes : A Comparative Analysis of the Current Reference Values. Anemia. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-464996
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-464996