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Brentuximab Vedotin Treatment for Primary Refractory Hodgkin Lymphoma
Joint Authors
Chen, Huei-Yung
Yeh, Shyh-An
Wu, Hung-Bo
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-02
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Up to 40% of patients with advanced Hodgkin lymphoma (HL) become refractory or relapsed after current standard chemotherapy, among which primary refractory HL confers a particularly poor outcome.
With intensive salvage chemotherapy and autologous stem cell transplantation, the long-term remission rate for these patients was only 30%, but more selective treatments with higher therapeutic index are needed.
We report the experience of using a new anti-CD30 immunotoxin, brentuximab vedotin, in salvage treatment of a 30-year-old woman with primary refractory Hodgkin lymphoma.
The patient presented with SVC syndrome due to the bulky mediastinal tumor and was confirmed to have classical Hodgkin lymphoma, nodular sclerosis type, stage IIIA.
The tumor responded to induction chemotherapy transiently, but local progression was noted during subsequent cycles of treatment.
Salvage radiotherapy to the mediastinal tumor, obtained no remission but was followed by rapid in-field progression and then lung metastasis.
She declined stem cell transplantation and received salvage brentuximab vedotin (BV) therapy, which induced dramatic shrinkage of tumor without significant side effects.
Serial followup of PET/CT imaging confirmed a rapid and continuous complete remission for 12 months.
Although durability of the remission needs further observation, this case illustrates the excellent efficacy of brentuximab vedotin in primary refractory Hodgkin lymphoma.
American Psychological Association (APA)
Wu, Hung-Bo& Yeh, Shyh-An& Chen, Huei-Yung. 2013. Brentuximab Vedotin Treatment for Primary Refractory Hodgkin Lymphoma. Case Reports in Hematology،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-465009
Modern Language Association (MLA)
Wu, Hung-Bo…[et al.]. Brentuximab Vedotin Treatment for Primary Refractory Hodgkin Lymphoma. Case Reports in Hematology No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-465009
American Medical Association (AMA)
Wu, Hung-Bo& Yeh, Shyh-An& Chen, Huei-Yung. Brentuximab Vedotin Treatment for Primary Refractory Hodgkin Lymphoma. Case Reports in Hematology. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-465009
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465009