Human T Cell and Antibody-Mediated Responses to the Mycobacterium tuberculosis Recombinant 85A, 85B, and ESAT-6 Antigens
Joint Authors
Macedo, Gilson Costa
Weinreich, Helena Rachel
Bozzi, Adriana
Bafica, Andre
Teixeira, Henrique C.
Oliveira, Sergio Costa
Source
Clinical and Developmental Immunology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Tuberculosis remains a major health problem throughout the world causing large number of deaths.
Effective disease control and eradication programs require the identification of major antigens recognized by the protective responses against M.
tuberculosis.
In this study, we have investigated humoral and cellular immune responses to M.
tuberculosis-specific Ag85A, Ag85B, and ESAT-6 antigens in Brazilian patients with pulmonary (P, n=13) or extrapulmonary (EP, n=12) tuberculosis, patients undergoing chemotherapy (PT, n=23), and noninfected healthy individuals (NI, n=7).
Compared to NI, we observed increased levels of IgG1 responses to Ag85B and ESAT-6 in P and PT groups.
Regarding cellular immunity, Ag85A and ESAT-6 were able to discriminate P, PT, and EP patients from healthy individuals by IFN-γ production and P and PT groups from EP individuals by production of TNF-α.
In summary, these findings demonstrate the ability of Ag85A, Ag85B, and ESAT-6 to differentiate TB patients from controls by IgG1, IFN-γ and TNF-α production.
American Psychological Association (APA)
Macedo, Gilson Costa& Bozzi, Adriana& Weinreich, Helena Rachel& Bafica, Andre& Teixeira, Henrique C.& Oliveira, Sergio Costa. 2010. Human T Cell and Antibody-Mediated Responses to the Mycobacterium tuberculosis Recombinant 85A, 85B, and ESAT-6 Antigens. Clinical and Developmental Immunology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-465030
Modern Language Association (MLA)
Macedo, Gilson Costa…[et al.]. Human T Cell and Antibody-Mediated Responses to the Mycobacterium tuberculosis Recombinant 85A, 85B, and ESAT-6 Antigens. Clinical and Developmental Immunology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-465030
American Medical Association (AMA)
Macedo, Gilson Costa& Bozzi, Adriana& Weinreich, Helena Rachel& Bafica, Andre& Teixeira, Henrique C.& Oliveira, Sergio Costa. Human T Cell and Antibody-Mediated Responses to the Mycobacterium tuberculosis Recombinant 85A, 85B, and ESAT-6 Antigens. Clinical and Developmental Immunology. 2010. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-465030
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465030