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Susceptibility of Dermatophytes to Thiabendazole Using CLSI Broth Macrodilution
Joint Authors
Robledo-Leal, Efrén
Elizondo-Zertuche, Mariana
González, Gloria M.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-13
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Objective.
To evaluate in vitro antifungal activity of thiabendazole against strains of dermatophytes using a reference method for filamentous fungi.
Materials and Methods.
Dermatophytes’ susceptibility to thiabendazole (TBZ) and fluconazole (FCZ) was evaluated using macrodilution method of protocol M38-A2 of the Clinical and Laboratory Standards Institute (CLSI).
Results.
MIC ranges of TBZ for all strains were narrower and/or smaller than those of FCZ.
TBZ showed a significantly greater potency than FCZ (P=0.05) against all isolates.
Discussion.
Although there have been approaches to evaluate the antifungal activity of TBZ in human mycoses, no tests had been made with a standardized protocol.
Susceptibility data resulted from this study shows that although TBZ is not a particularly strong inhibitor of dermatophytes, it displays a stable and constant effect against all isolates tested.
Conclusion.
Results show that TBZ is more effective against strains of dermatophytes than FCZ.
We acknowledge the antifungal effect of TBZ against dermatophyte isolates.
American Psychological Association (APA)
Robledo-Leal, Efrén& Elizondo-Zertuche, Mariana& González, Gloria M.. 2012. Susceptibility of Dermatophytes to Thiabendazole Using CLSI Broth Macrodilution. ISRN Dermatology،Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-465064
Modern Language Association (MLA)
Robledo-Leal, Efrén…[et al.]. Susceptibility of Dermatophytes to Thiabendazole Using CLSI Broth Macrodilution. ISRN Dermatology No. 2012 (2012), pp.1-3.
https://search.emarefa.net/detail/BIM-465064
American Medical Association (AMA)
Robledo-Leal, Efrén& Elizondo-Zertuche, Mariana& González, Gloria M.. Susceptibility of Dermatophytes to Thiabendazole Using CLSI Broth Macrodilution. ISRN Dermatology. 2012. Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-465064
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465064