Tanshinol Attenuates the Deleterious Effects of Oxidative Stress on Osteoblastic Differentiation via WntFoxO3a Signaling
Joint Authors
Chen, Yahui
Su, Yanjie
Sun, Xuegang
Li, Gang
Wu, Tie
Wang, Dongtao
Yang, Yajun
Cui, Liao
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-31
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
There is now increasing evidence which suggests a pivotal role for oxidative stress in the development and progression of osteoporosis.
We confirm herein the protective effects of natural antioxidant Tanshinol against oxidative stress in osteoblastic differentiation and the underlying mechanism.
Our results show that hydrogen peroxide (H2O2) leads to accumulation of reactive oxygen species (ROS), decrease in cell viability, cell cycle arrest and apoptosis in a caspase-3-dependent manner, and inhibition of osteoblastic differentiation.
Tanshinol reverses these deleterious consequence triggered by oxidative stress.
Moreover, under the condition of oxidative stress, Tanshinol suppresses the activation of FoxO3a transcription factor and expressions of its target genes Gadd45a and catalase (CAT) and simultaneously counteracts the inhibition of Wnt signalling and expressions of target genes Axin2, alkaline phosphatase (ALP), and Osteoprotegerin (OPG).
The findings are further consolidated using FoxO3a siRNA interference and overexpression of Tcf4.
The results illustrate that Tanshinol attenuates oxidative stress via down-regulation of FoxO3a signaling, and rescues the decrease of osteoblastic differentiation through upregulation of Wnt signal under oxidative stress.
The present findings suggest that the beneficial effects of Tanshinol may be adopted as a novel therapeutic approach in recently recognized conditions of niche targeting osteoporosis.
American Psychological Association (APA)
Yang, Yajun& Su, Yanjie& Wang, Dongtao& Chen, Yahui& Wu, Tie& Li, Gang…[et al.]. 2013. Tanshinol Attenuates the Deleterious Effects of Oxidative Stress on Osteoblastic Differentiation via WntFoxO3a Signaling. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-465070
Modern Language Association (MLA)
Yang, Yajun…[et al.]. Tanshinol Attenuates the Deleterious Effects of Oxidative Stress on Osteoblastic Differentiation via WntFoxO3a Signaling. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-18.
https://search.emarefa.net/detail/BIM-465070
American Medical Association (AMA)
Yang, Yajun& Su, Yanjie& Wang, Dongtao& Chen, Yahui& Wu, Tie& Li, Gang…[et al.]. Tanshinol Attenuates the Deleterious Effects of Oxidative Stress on Osteoblastic Differentiation via WntFoxO3a Signaling. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-465070
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465070