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Antibody-Mediated Rejection in Heart Transplantation : Case Presentation with a Review of Current International Guidelines
Joint Authors
Arabia, Francisco A.
Tazelaar, Henry D.
Kalya, Anantharam V.
Scott, Robert L.
Jaroszewski, Dawn E.
Pajaro, Octavio E.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Antibody-mediated rejection (AMR) (humoral rejection) of cardiac allografts remains difficult to diagnose and treat.
Interest in AMR of cardiac allografts has increased over the last decade as it has become apparent that untreated humoral rejection threatens graft and patient survival.
An international and multidisciplinary consensus group has formulated guidelines for the diagnosis and treatment of AMR and established that identification of circulating or donor-specific antibodies is not required and that asymptomatic AMR, that is, biopsy-proven AMR without cardiac dysfunction is a real entity with worsened prognosis.
Strict criteria for the diagnosis of cardiac AMR have not been firmly established, although the diagnosis relies heavily on tissue pathological findings.
Therapy remains largely empirical.
We review an unfortunate experience with one of our patients and summarize recommended criteria for the diagnosis of AMR and potential treatment schemes with a focus on current limitations and the need for future research and innovation.
American Psychological Association (APA)
Pajaro, Octavio E.& Jaroszewski, Dawn E.& Scott, Robert L.& Kalya, Anantharam V.& Tazelaar, Henry D.& Arabia, Francisco A.. 2011. Antibody-Mediated Rejection in Heart Transplantation : Case Presentation with a Review of Current International Guidelines. Journal of Transplantation،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-465078
Modern Language Association (MLA)
Pajaro, Octavio E.…[et al.]. Antibody-Mediated Rejection in Heart Transplantation : Case Presentation with a Review of Current International Guidelines. Journal of Transplantation No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-465078
American Medical Association (AMA)
Pajaro, Octavio E.& Jaroszewski, Dawn E.& Scott, Robert L.& Kalya, Anantharam V.& Tazelaar, Henry D.& Arabia, Francisco A.. Antibody-Mediated Rejection in Heart Transplantation : Case Presentation with a Review of Current International Guidelines. Journal of Transplantation. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-465078
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465078