Predictors of Impaired Glucose Regulation in Patients with Non-Alcoholic Fatty Liver Disease
Joint Authors
Tsiavou, Anastasia
Hatziagelaki, Erifili
Dimitriadis, George
Karageorgopoulos, Drosos E.
Falagas, Matthew E.
Chounta, Athina
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
Many patients with non-alcoholic fatty liver disease (NAFLD) have impaired glucose regulation or type 2 diabetes mellitus (DM).
We investigated characteristics of NAFLD patients associated with hyperglycemia.
Methods.
During a 2-hour oral glucose tolerance test (OGTT), serum glucose and insulin were measured in 152 NAFLD patients.
Results.
48.7% of NAFLD patients had hyperglycemia.
Age (odds ratio (OR)=1.08, 95% confidence interval (CI): 1.03–1.13), body mass index (BMI) (OR=1.12, 95% CI: 1.01–1.25), and lower high-density lipoprotein cholesterol (HDL-C) (OR=0.95, 95% CI: 0.92–0.98) proved to be independent predictors of hyperglycemia.
After OGTT, 30 min insulin was lower in hyperglycemic patients (74.2±49.7 versus 94.5±53.9 μIU/mL, P=0.02), while 90 min insulin (170.1±84.6 versus 122.9±97.7 μU/mL, P=0.01) and 120 min insulin (164.0±101.2 versus 85.3±61.9 μIU/mL, P<0.01) were higher.
Conclusions.
NAFLD patients with higher BMI, lower HDL-C, or older age were more likely to have impaired glucose metabolism.
An OGTT could be of value for early diagnosis of DM among this population.
American Psychological Association (APA)
Hatziagelaki, Erifili& Karageorgopoulos, Drosos E.& Chounta, Athina& Tsiavou, Anastasia& Falagas, Matthew E.& Dimitriadis, George. 2011. Predictors of Impaired Glucose Regulation in Patients with Non-Alcoholic Fatty Liver Disease. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-465083
Modern Language Association (MLA)
Hatziagelaki, Erifili…[et al.]. Predictors of Impaired Glucose Regulation in Patients with Non-Alcoholic Fatty Liver Disease. Experimental Diabetes Research No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-465083
American Medical Association (AMA)
Hatziagelaki, Erifili& Karageorgopoulos, Drosos E.& Chounta, Athina& Tsiavou, Anastasia& Falagas, Matthew E.& Dimitriadis, George. Predictors of Impaired Glucose Regulation in Patients with Non-Alcoholic Fatty Liver Disease. Experimental Diabetes Research. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-465083
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465083