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Rodent Models for Metabolic Syndrome Research
Joint Authors
Brown, Lindsay
Panchal, Sunil K.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-30
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Rodents are widely used to mimic human diseases to improve understanding of the causes and progression of disease symptoms and to test potential therapeutic interventions.
Chronic diseases such as obesity, diabetes and hypertension, together known as the metabolic syndrome, are causing increasing morbidity and mortality.
To control these diseases, research in rodent models that closely mimic the changes in humans is essential.
This review will examine the adequacy of the many rodent models of metabolic syndrome to mimic the causes and progression of the disease in humans.
The primary criterion will be whether a rodent model initiates all of the signs, especially obesity, diabetes, hypertension and dysfunction of the heart, blood vessels, liver and kidney, primarily by diet since these are the diet-induced signs in humans with metabolic syndrome.
We conclude that the model that comes closest to fulfilling this criterion is the high carbohydrate, high fat-fed male rodent.
American Psychological Association (APA)
Panchal, Sunil K.& Brown, Lindsay. 2010. Rodent Models for Metabolic Syndrome Research. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-465085
Modern Language Association (MLA)
Panchal, Sunil K.& Brown, Lindsay. Rodent Models for Metabolic Syndrome Research. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-465085
American Medical Association (AMA)
Panchal, Sunil K.& Brown, Lindsay. Rodent Models for Metabolic Syndrome Research. Journal of Biomedicine and Biotechnology. 2010. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-465085
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465085