Striated Muscle as Implantation Site for Transplanted Pancreatic Islets
Joint Authors
Carlsson, Per-Ola
Eriksson, Olof
Espes, Daniel
Lau, Joey
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-07
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Islet transplantation is an attractive treatment for selected patients with brittle type 1 diabetes.
In the clinical setting, intraportal transplantation predominates.
However, due to extensive early islet cell death, the quantity of islets needed to restore glucose homeostasis requires in general a minimum of two donors.
Moreover, the deterioration of islet function over time results in few insulin-independent patients after five-year followup.
Specific obstacles to the success of islet transplantation include site-specific concerns for the liver such as the instant blood mediated inflammatory reaction, islet lipotoxicity, low oxygen tension, and poor revascularization, impediments that have led to the developing interest for alternative implantation sites over recent years.
Within preclinical settings, several alternative sites have now been investigated and proven favorable in various aspects.
Muscle is considered a very promising site and has physiologically properties and technical advantages that could make it optimal for islet transplantation.
American Psychological Association (APA)
Espes, Daniel& Eriksson, Olof& Lau, Joey& Carlsson, Per-Ola. 2011. Striated Muscle as Implantation Site for Transplanted Pancreatic Islets. Journal of Transplantation،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-465091
Modern Language Association (MLA)
Espes, Daniel…[et al.]. Striated Muscle as Implantation Site for Transplanted Pancreatic Islets. Journal of Transplantation No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-465091
American Medical Association (AMA)
Espes, Daniel& Eriksson, Olof& Lau, Joey& Carlsson, Per-Ola. Striated Muscle as Implantation Site for Transplanted Pancreatic Islets. Journal of Transplantation. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-465091
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465091