Astragalus in the Prevention of Upper Respiratory Tract Infection in Children with Nephrotic Syndrome : Evidence-Based Clinical Practice
Joint Authors
Lu, Fuhua
Mao, Wei
Zou, Chuan
Liu, Xusheng
Wu, Yuchi
Su, Guobin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aims.
To explore whether Astragalus or its formulations could prevent upper respiratory infection in children with nephrotic syndrome and how best to use it.
Methods.
We transformed a common clinical question in practice to an answerable question according to the PICO principle.
Databases, including the Cochrane Library (Issue 5, 2012), PUBMED (1966–2012.8), CBM (1978–2012.8), VIP (1989–2012.8), and CNKI (1979–2012.8), were searched to identify Cochrane systematic reviews and clinical trials.
Then, the quality of and recommendations from the clinical evidence were evaluated using the GRADEpro software.
Results.
The search yielded 537 papers.
Only two studies with high validity were included for synthesis calculations.
The results showed that Astragalus granules could effectively reduce URTI in children with nephrotic syndrome compared with prednisone treatment alone (23.9% versus 42.9%; RR = 0.56 and 95% CI = 0.33–0.93).
The dose of Astragalus granules was 2.25 gram (equivalent to 15 gram crude Astragalus) twice per day, at least for 3–6 months.
The level of evidence quality was low, but we still recommended the evidence to the patient according to GRADEpro with the opinion of the expert.
Followup showed the incidence of URTI in this child decreased significantly.
Conclusions.
Astragalus granules may reduce the incidence of URTI in children with nephrotic syndrome.
American Psychological Association (APA)
Zou, Chuan& Su, Guobin& Wu, Yuchi& Lu, Fuhua& Mao, Wei& Liu, Xusheng. 2013. Astragalus in the Prevention of Upper Respiratory Tract Infection in Children with Nephrotic Syndrome : Evidence-Based Clinical Practice. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-465102
Modern Language Association (MLA)
Zou, Chuan…[et al.]. Astragalus in the Prevention of Upper Respiratory Tract Infection in Children with Nephrotic Syndrome : Evidence-Based Clinical Practice. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-465102
American Medical Association (AMA)
Zou, Chuan& Su, Guobin& Wu, Yuchi& Lu, Fuhua& Mao, Wei& Liu, Xusheng. Astragalus in the Prevention of Upper Respiratory Tract Infection in Children with Nephrotic Syndrome : Evidence-Based Clinical Practice. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-465102
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465102