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Molecular Mechanisms of Trastuzumab Resistance in HER2 Overexpressing Breast Cancer
Joint Authors
Jasnis, María A.
Fiszman, Gabriel L.
Source
International Journal of Breast Cancer
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-06
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The epidermal growth factor receptor 2 (HER2) is a tyrosine kinase overexpressed in nearly 20% to 25% of invasive breast cancers.
Trastuzumab is a humanized monoclonal antibody that targets HER2.
The majority of patients with metastatic breast cancer initially respond to trastuzumab, however, within 1 year of treatment disease progresses.
Several molecular mechanisms have been described as contributing to the development of trastuzumab resistance.
They could be grouped as impaired access of trastuzumab to HER2, upregulation of HER2 downstream signaling pathways, signaling of alternative pathways, and impaired immune antitumor mechanisms.
However, since many of them have overlapping effects, it would be of great clinical impact to identify the principal signaling pathways involved in drug resistance.
Significant efforts are being applied to find other therapeutic modalities besides trastuzumab treatment to be used alone or in combination with current modalities.
American Psychological Association (APA)
Fiszman, Gabriel L.& Jasnis, María A.. 2011. Molecular Mechanisms of Trastuzumab Resistance in HER2 Overexpressing Breast Cancer. International Journal of Breast Cancer،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-465112
Modern Language Association (MLA)
Fiszman, Gabriel L.& Jasnis, María A.. Molecular Mechanisms of Trastuzumab Resistance in HER2 Overexpressing Breast Cancer. International Journal of Breast Cancer No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-465112
American Medical Association (AMA)
Fiszman, Gabriel L.& Jasnis, María A.. Molecular Mechanisms of Trastuzumab Resistance in HER2 Overexpressing Breast Cancer. International Journal of Breast Cancer. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-465112
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465112