Bone Regeneration in Artificial Jaw Cleft by Use of Carbonated Hydroxyapatite Particles and Mesenchymal Stem Cells Derived from Iliac Bone
Joint Authors
Tanimoto, Kotaro
Oki, Nanae
Tanne, Yuki
Tanne, Kazuo
Sumi, Keisuke
Awada, Tetsuya
Yoshioka, Motoko
Kato, Yukio
Sugiyama, Masaru
Source
International Journal of Dentistry
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives of the Study.
Cleft lip and palate (CLP) is a prevalent congenital anomaly in the orofacial region.
Autogenous iliac bone grafting has been frequently employed for the closure of bone defects at the jaw cleft site.
Since the related surgical procedures are quite invasive for patients, it is of great importance to develop a new less invasive technique.
The aim of this study was to examine bone regeneration with mesenchyme stem cells (MSCs) for the treatment of bone defect in artificially created jaw cleft in dogs.
Materials and Methods.
A bone defect was prepared bilaterally in the upper incisor regions of beagle dogs.
MSCs derived from iliac bone marrow were cultured and transplanted with carbonated hydroxyapatite (CAP) particles into the bone defect area.
The bone regeneration was evaluated by standardized occlusal X-ray examination and histological observation.
Results.
Six months after the transplantation, perfect closure of the jaw cleft was achieved on the experimental side.
The X-ray and histological examination revealed that the regenerated bone on the experimental side was almost equivalent to the original bone adjoining the jaw cleft.
Conclusion.
It was suggested that the application of MSCs with CAP particles can become a new treatment modality for bone regeneration for CLP patients.
American Psychological Association (APA)
Yoshioka, Motoko& Tanimoto, Kotaro& Tanne, Yuki& Sumi, Keisuke& Awada, Tetsuya& Oki, Nanae…[et al.]. 2012. Bone Regeneration in Artificial Jaw Cleft by Use of Carbonated Hydroxyapatite Particles and Mesenchymal Stem Cells Derived from Iliac Bone. International Journal of Dentistry،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-465130
Modern Language Association (MLA)
Yoshioka, Motoko…[et al.]. Bone Regeneration in Artificial Jaw Cleft by Use of Carbonated Hydroxyapatite Particles and Mesenchymal Stem Cells Derived from Iliac Bone. International Journal of Dentistry No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-465130
American Medical Association (AMA)
Yoshioka, Motoko& Tanimoto, Kotaro& Tanne, Yuki& Sumi, Keisuke& Awada, Tetsuya& Oki, Nanae…[et al.]. Bone Regeneration in Artificial Jaw Cleft by Use of Carbonated Hydroxyapatite Particles and Mesenchymal Stem Cells Derived from Iliac Bone. International Journal of Dentistry. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-465130
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465130