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The Catalytic Machinery of a Key Enzyme in Amino Acid Biosynthesis
Joint Authors
Liu, Xuying
Faehnle, Christopher R.
Moore, Roger A.
Arachea, Buenafe T.
Pavlovsky, Alexander G.
Viola, Ronald E.
Blanco, Julio
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The aspartate pathway of amino acid biosynthesis is essential for all microbial life but is absent in mammals.
Characterizing the enzyme-catalyzed reactions in this pathway can identify new protein targets for the development of antibiotics with unique modes of action.
The enzyme aspartate β-semialdehyde dehydrogenase (ASADH) catalyzes an early branch point reaction in the aspartate pathway.
Kinetic, mutagenic, and structural studies of ASADH from various microbial species have been used to elucidate mechanistic details and to identify essential amino acids involved in substrate binding, catalysis, and enzyme regulation.
Important structural and functional differences have been found between ASADHs isolated from these bacterial and fungal organisms, opening the possibility for developing species-specific antimicrobial agents that target this family of enzymes.
American Psychological Association (APA)
Viola, Ronald E.& Faehnle, Christopher R.& Blanco, Julio& Moore, Roger A.& Liu, Xuying& Arachea, Buenafe T.…[et al.]. 2010. The Catalytic Machinery of a Key Enzyme in Amino Acid Biosynthesis. Journal of Amino Acids،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-465132
Modern Language Association (MLA)
Viola, Ronald E.…[et al.]. The Catalytic Machinery of a Key Enzyme in Amino Acid Biosynthesis. Journal of Amino Acids No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-465132
American Medical Association (AMA)
Viola, Ronald E.& Faehnle, Christopher R.& Blanco, Julio& Moore, Roger A.& Liu, Xuying& Arachea, Buenafe T.…[et al.]. The Catalytic Machinery of a Key Enzyme in Amino Acid Biosynthesis. Journal of Amino Acids. 2010. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-465132
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465132