Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I
Joint Authors
Jun, Yang
Yan, Wen
Yuan, Lian-Chao
Zhong-Yi, Zheng
Duthie, Malcolm S.
Li, Huan-Ying
Qiong-Hua, Pan
Reed, Steven G.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Leprosy is a disabling chronic infection, with insidious onset that often evades early detection.
In order to detect new leprosy cases in a timely manner, we conducted surveillance visits in some difficult-to-reach mountain areas in South West China where the disease is still prevalent.
Our data confirm that Chinese multibacillary (MB) leprosy patients have strong antibody responses against Mycobacterium leprae antigens ND-O-BSA and LID-1.
Contacts of clinically diagnosed patients were then monitored at regular intervals by both physical examinations and the laboratory determination of antibody responses in sera collected during these examinations.
Elevations in antibody titers indicated the onset of MB leprosy in one of the contacts, and diagnosis was subsequently confirmed on physical examination.
Our data indicate that rising antibody titers can be used as a trigger for physical examination or increased monitoring of particular individuals in order to provide early leprosy diagnosis.
American Psychological Association (APA)
Qiong-Hua, Pan& Zhong-Yi, Zheng& Jun, Yang& Yan, Wen& Yuan, Lian-Chao& Li, Huan-Ying…[et al.]. 2013. Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I. Journal of Tropical Medicine،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-465151
Modern Language Association (MLA)
Qiong-Hua, Pan…[et al.]. Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I. Journal of Tropical Medicine No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-465151
American Medical Association (AMA)
Qiong-Hua, Pan& Zhong-Yi, Zheng& Jun, Yang& Yan, Wen& Yuan, Lian-Chao& Li, Huan-Ying…[et al.]. Early Revelation of Leprosy in China by Sequential Antibody Analyses with LID-1 and PGL-I. Journal of Tropical Medicine. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-465151
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465151