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A New Microarray System to Detect Streptococcus pneumoniae Serotypes
Joint Authors
Yamada, Keiko
Hasegawa, Yoshinori
Yagi, Testuya
Tomita, Yuka
Okamoto, Akira
Ohta, Michio
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-09
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Streptococcus pneumoniae, one of the most common gram-positive pathogens to colonize the human upper respiratory tract, is responsible for many severe infections, including meningitis and bacteremia.
A 23-valent pneumococcal vaccine is available to protect against the 23 S.
pneumoniae serotypes responsible for 90% of reported bacteremic infections.
Unfortunately, current S.
pneumoniae serotype testing requires a large panel of expensive antisera, assay results may be subjective, and serotype cross-reactions are common.
For this study, we designed an oligonucleotide-based DNA microarray to identify glycosyltransferase gene sequences specific to each vaccine-related serotype.
Out of 56 isolates representing different serotypes, only one isolate, representing serotype 23A, was not detected correctly as it could not be distinguished from serotype 23F.
Our data suggest that the microarray provides a more cost-effective and reliable way of monitoring pneumococcal capsular types.
American Psychological Association (APA)
Tomita, Yuka& Okamoto, Akira& Yamada, Keiko& Yagi, Testuya& Hasegawa, Yoshinori& Ohta, Michio. 2011. A New Microarray System to Detect Streptococcus pneumoniae Serotypes. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-21.
https://search.emarefa.net/detail/BIM-465156
Modern Language Association (MLA)
Tomita, Yuka…[et al.]. A New Microarray System to Detect Streptococcus pneumoniae Serotypes. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-21.
https://search.emarefa.net/detail/BIM-465156
American Medical Association (AMA)
Tomita, Yuka& Okamoto, Akira& Yamada, Keiko& Yagi, Testuya& Hasegawa, Yoshinori& Ohta, Michio. A New Microarray System to Detect Streptococcus pneumoniae Serotypes. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-21.
https://search.emarefa.net/detail/BIM-465156
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465156