Functional Implications of Glycogen Synthase Kinase-3-Mediated Tau Phosphorylation
Joint Authors
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Tau is primarily a neuronal microtubule-associated protein that has functions related to the stabilisation of microtubules.
Phosphorylation of tau is an important dynamic and regulatory element involved in the binding of tau to tubulin.
Thus, highly phosphorylated tau is more likely to be present in the cytosolic compartment of neurons, whereas reduced phosphate burden allows tau to bind to and stabilise the microtubule cytoskeleton.
Highly phosphorylated forms of tau are deposited in the brain in a range of neurodegenerative disorders including Alzheimer's disease, progressive supranuclear palsy, and frontotemporal lobar degeneration associated with Pick bodies.
A key candidate kinase for both physiological and pathological tau phosphorylation is glycogen synthase kinase-3 (GSK-3).
Multiple phosphorylation sites have been identified on tau exposed to GSK-3 in vitro and in cells.
In this review, we highlight recent data suggesting a role for GSK-3 activity on physiological tau function and on tau dysfunction in neurodegenerative disease.
American Psychological Association (APA)
Hanger, Diane P.& Noble, Wendy. 2011. Functional Implications of Glycogen Synthase Kinase-3-Mediated Tau Phosphorylation. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-465167
Modern Language Association (MLA)
Hanger, Diane P.& Noble, Wendy. Functional Implications of Glycogen Synthase Kinase-3-Mediated Tau Phosphorylation. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-465167
American Medical Association (AMA)
Hanger, Diane P.& Noble, Wendy. Functional Implications of Glycogen Synthase Kinase-3-Mediated Tau Phosphorylation. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-465167
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465167