Sustained and Transient Contributions to the Rat Dark-Adapted Electroretinogram b-Wave
Joint Authors
Dang, Trung M.
Bui, Bang V.
Vingrys, Algis J.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-06
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The most dominant feature of the electroretinogram, the b-wave, is thought to reflect ON-bipolar cell responses.
However, a number of studies suggest that the b-wave is made up of several components.
We consider the composition of the rat b-wave by subtracting corneal negative components obtained using intravitreal application of pharmacological agents to remove postreceptoral responses.
By analyzing the intensity-response characteristic of the PII across a range of fixed times during and after a light step, we find that the rat isolated PII has 2 components.
The first has fast rise and decay characteristics with a low sensitivity to light.
GABAc-mediated inhibitory pathways enhance this transient-ON component to manifest increased and deceased sensitivity to light at shorter (<160 ms) and longer times, respectively.
The second component has slower temporal characteristics but is more sensitive to light.
GABAc-mediated inhibition enhances this sustained-ON component but has little effect on its sensitivity to light.
After stimulus offset, both transient and sustained components return to baseline, and a long latency sustained positive component becomes apparent.
The light sensitivities of transient-ON and sustained-OFF components are consistent with activity arising from cone ON- and OFF-bipolar cells, whereas the sustained-ON component is likely to arise from rod bipolar cells.
American Psychological Association (APA)
Dang, Trung M.& Vingrys, Algis J.& Bui, Bang V.. 2013. Sustained and Transient Contributions to the Rat Dark-Adapted Electroretinogram b-Wave. Journal of Ophthalmology،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-465182
Modern Language Association (MLA)
Dang, Trung M.…[et al.]. Sustained and Transient Contributions to the Rat Dark-Adapted Electroretinogram b-Wave. Journal of Ophthalmology No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-465182
American Medical Association (AMA)
Dang, Trung M.& Vingrys, Algis J.& Bui, Bang V.. Sustained and Transient Contributions to the Rat Dark-Adapted Electroretinogram b-Wave. Journal of Ophthalmology. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-465182
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465182