An Interstitial 20q11.21 Microdeletion Causing Mild Intellectual Disability and Facial Dysmorphisms
Joint Authors
Iourov, Ivan Y.
Kurinnaia, Oxana S.
Vorsanova, Svetlana G.
Yurov, Yuri B.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-14
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We report a case of an interstitial chromosome 20q11.21 microdeletion in a 7-year-old male child presenting with mild intellectual disability and facial dysmorphisms.
Array comparative genomic hybridization (CGH) has shown that the deletion resulted in the loss of 68 genes, among which 5 genes (COX4I2, MYLK2, ASXL1, DNMT3B, and SNTA1) are disease causing.
The size of the deletion was estimated to span 2.6 Mb.
Only three cases of deletions encompassing this chromosomal region have been reported.
The phenotype of the index patient was found to resemble the mildest cases of Bohring-Opitz syndrome that is caused by ASXL1 mutations.
An in silico evaluation of the deleted genomic region has shown that benign genomic variations have never been observed to affect the ASXL1 gene, in contrast to the other disease-causing genes.
As a result, it was suggested that ASXL1 loss is likely to be the main cause of the phenotypic manifestations.
The present case report indicates that a loss of the disease-causing gene can produce a milder phenotype of a single gene condition.
American Psychological Association (APA)
Iourov, Ivan Y.& Vorsanova, Svetlana G.& Kurinnaia, Oxana S.& Yurov, Yuri B.. 2013. An Interstitial 20q11.21 Microdeletion Causing Mild Intellectual Disability and Facial Dysmorphisms. Case Reports in Genetics،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-465191
Modern Language Association (MLA)
Iourov, Ivan Y.…[et al.]. An Interstitial 20q11.21 Microdeletion Causing Mild Intellectual Disability and Facial Dysmorphisms. Case Reports in Genetics No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-465191
American Medical Association (AMA)
Iourov, Ivan Y.& Vorsanova, Svetlana G.& Kurinnaia, Oxana S.& Yurov, Yuri B.. An Interstitial 20q11.21 Microdeletion Causing Mild Intellectual Disability and Facial Dysmorphisms. Case Reports in Genetics. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-465191
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465191