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Immunomodulatory Effects of Mesenchymal Stromal Cells Revisited in the Context of Inflammatory Cardiomyopathy
Joint Authors
Volk, Hans-Dieter
Miteva, Kapka
Van Linthout, Sophie
Tschöpe, Carsten
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-19
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Myocarditis is a common inflammatory cardiomyopathy, associated with cardiomyocyte apoptosis, which can lead to chronic left ventricular dysfunction.
Under conventional heart failure therapy, inflammatory cardiomyopathy typically has a progressive course, indicating a need for alternative therapeutic strategies to improve long-term outcomes.
Experimental and clinical studies consistently support the application of cellular transplantation as a strategy to improve myocardial function.
Mesenchymal stromal cells (MSCs) mediate distinct paracrine effects supporting endogenous regeneration, but most important are their remarkable immunoregulatory properties.
In this review, an overview of current knowledge on immunopathology in myocarditis will be given.
Furthermore, current research regarding the immunomodulatory properties of MSCs in the context of myocarditis will be discussed.
Finally, the impact of MSC priming by the environment on their functionality and the advantages of systemic administration of MSCs under myocarditis are outlined.
American Psychological Association (APA)
Miteva, Kapka& Van Linthout, Sophie& Volk, Hans-Dieter& Tschöpe, Carsten. 2013. Immunomodulatory Effects of Mesenchymal Stromal Cells Revisited in the Context of Inflammatory Cardiomyopathy. Stem Cells International،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-465198
Modern Language Association (MLA)
Miteva, Kapka…[et al.]. Immunomodulatory Effects of Mesenchymal Stromal Cells Revisited in the Context of Inflammatory Cardiomyopathy. Stem Cells International No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-465198
American Medical Association (AMA)
Miteva, Kapka& Van Linthout, Sophie& Volk, Hans-Dieter& Tschöpe, Carsten. Immunomodulatory Effects of Mesenchymal Stromal Cells Revisited in the Context of Inflammatory Cardiomyopathy. Stem Cells International. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-465198
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465198