The Amyloid Precursor Protein Intracellular Domain-Fe65 Multiprotein Complexes : A Challenge to the Amyloid Hypothesis for Alzheimer's Disease?
Joint Authors
González-Billault, Christian
Bórquez, Daniel A.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Since its proposal in 1994, the amyloid cascade hypothesis has prevailed as the mainstream research subject on the molecular mechanisms leading to the Alzheimer's disease (AD).
Most of the field had been historically based on the role of the different forms of aggregation of β-amyloid peptide (Aβ).
However, a soluble intracellular fragment termed amyloid precursor protein (APP) intracellular domain (AICD) is produced in conjunction with Aβ fragments.
This peptide had been shown to be highly toxic in both culture neurons and transgenic mice models.
With the advent of this new toxic fragment, the centerpiece for the ethiology of the disease may be changed.
This paper discusses the potential role of multiprotein complexes between the AICD and its adapter protein Fe65 and how this could be a potentially important new agent in the neurodegeneration observed in the AD.
American Psychological Association (APA)
Bórquez, Daniel A.& González-Billault, Christian. 2012. The Amyloid Precursor Protein Intracellular Domain-Fe65 Multiprotein Complexes : A Challenge to the Amyloid Hypothesis for Alzheimer's Disease?. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-465201
Modern Language Association (MLA)
Bórquez, Daniel A.& González-Billault, Christian. The Amyloid Precursor Protein Intracellular Domain-Fe65 Multiprotein Complexes : A Challenge to the Amyloid Hypothesis for Alzheimer's Disease?. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-465201
American Medical Association (AMA)
Bórquez, Daniel A.& González-Billault, Christian. The Amyloid Precursor Protein Intracellular Domain-Fe65 Multiprotein Complexes : A Challenge to the Amyloid Hypothesis for Alzheimer's Disease?. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-465201
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465201