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Progesterone Interactions with the Cervix : Translational Implications for Term and Preterm Birth
Joint Authors
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-27
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The uterine cervix plays a vital role in maintaining pregnancy and an equally important role in allowing parturition to occur.
Progesterone, either endogenously produced or supplied exogenously, supports the function of the cervix in sustaining intrauterine pregnancy, and the withdrawal of progesterone, either through natural processes or pharmacologic intervention, leads to delivery which underscores the importance of the progesterone's biological activities manifest in normal gestation and pregnancy that ends prematurely.
Research crossing many scientific disciplines has demonstrated that progesterone is a pleotropic compound that affects the cervix through cytoplasmic and membrane receptors with profound effects on cellular and molecular functions that influence inflammatory cascades and extracellular matrix, both of which have consequences for parturition.
Beyond the local cell and molecular biology of progesterone, it has systemic effects of relevance to pregnancy as well.
This paper examines the biology of the cervix from its gross to cellular structure and biological activities of its cell and molecular processes that may be affected by progesterone.
The implications of these processes for preterm birth are explored, and direction of current research is in relation to translational medicine implications for diagnostic, prognostic, and therapeutic approaches to threatened preterm birth.
American Psychological Association (APA)
Larsen, Bryan& Hwang, Joseph. 2011. Progesterone Interactions with the Cervix : Translational Implications for Term and Preterm Birth. Infectious Diseases in Obstetrics and Gynecology،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-465216
Modern Language Association (MLA)
Larsen, Bryan& Hwang, Joseph. Progesterone Interactions with the Cervix : Translational Implications for Term and Preterm Birth. Infectious Diseases in Obstetrics and Gynecology No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-465216
American Medical Association (AMA)
Larsen, Bryan& Hwang, Joseph. Progesterone Interactions with the Cervix : Translational Implications for Term and Preterm Birth. Infectious Diseases in Obstetrics and Gynecology. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-465216
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465216