Lymph Node Transplantation and Its Immunological Significance in Animal Models
Joint Authors
Source
Clinical and Developmental Immunology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Lymph nodes (LNs) are distributed all over the body and whatever the site consists of the same cell populations.
However, there are great differences between LN from different draining areas.
For example, in mesenteric LN, homing molecules, for example, CCR9 and α4β7 integrin, were induced and cytokines, for example, IL-4, were produced on higher levels compared to peripheral LN.
To study the immunological functions of LN, LN transplantation was performed in some specific areas using different animal models.
Many groups investigated not only the regeneration of transplanted LN but also the induction of immune responses or tolerance after transplantation.
Existing differences between LNs were still detectable after transplantation.
Most important, stromal cells of the LN were identified as responsible for these differences.
They survive during regeneration and were shown to reconstruct not only the structure of the new LN but also the microenvironment.
American Psychological Association (APA)
Buettner, Manuela& Bode, Ulrike. 2011. Lymph Node Transplantation and Its Immunological Significance in Animal Models. Clinical and Developmental Immunology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-465227
Modern Language Association (MLA)
Buettner, Manuela& Bode, Ulrike. Lymph Node Transplantation and Its Immunological Significance in Animal Models. Clinical and Developmental Immunology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-465227
American Medical Association (AMA)
Buettner, Manuela& Bode, Ulrike. Lymph Node Transplantation and Its Immunological Significance in Animal Models. Clinical and Developmental Immunology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-465227
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465227